Results 91 to 100 of about 479,574 (232)
Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen +5 more
wiley +1 more source
Caso de identificación de un proyecto de inversión
, 2013 Este objeto educativo presenta una serie de pasos que le permiten al estudiante identificar, analizar y proponer un plan de inversión para la solución de un problema.Universidad del Norte, Instituto de Estudios Superiores en ...
Mendoza Pinedo, Alvaro
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Informe narrativo Plan Operativo Anual 2021. Resoluciones 0051 y 0210 de 2021
, 2021 ResumenUna vez superado el encierro estricto de 2020, la vigencia 2021 significó, entre otros temas a destacar, un retorno paulatino a la posnormalidad laboral institucional.
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ANTECEDENTES DE LA INTENCIÓN DE USO DE LOS SITIOS WEB DE COMPRAS COLECTIVAS
Revista EIALos sitios web de compras colectivas han adquirido importancia para la comercialización online de productos y servicios, pero los estudios sobre la aceptación de esta tecnología son escasos en el mundo e inexistentes en Colombia.
Ana María Villa Zapata +2 more
doaj
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
SPANISH COMPANY FOREIGN MARKET ENTRY [PDF]
The aim of this paper is to analyse the determinants of diversification mode (acquisition versus greenfield) through foreign direct investment considering various theories, such as those of mergers and acquisitions, transaction costs, the learning ...
Felipe Ruiz Moreno, Francisco J. Más
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FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Análisis de la inversión pública en salud: tendencias, impacto y desafíos globales
Revista Científica en Ciencias SocialesEl objetivo del estudio es analizar las tendencias, impactos y desafíos globales de la inversión pública en salud. Se empleó el enfoque cualitativo, nivel descriptivo mediante una revisión sistemática en Scopus, SciELO y Redalyc.
Liz Magaly Rodríguez Pérez
doaj +1 more source
SPG4 and Dementia: Expanding the Clinical Spectrum
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza +19 more
wiley +1 more source