Results 51 to 60 of about 8,387,502 (286)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Rentabilidad social de las inversiones públicas: Análisis Coste Beneficio del AVE Madrid-Valencia [PDF]

, 2013
El AVE se ha convertido en los últimos años en el principal receptor de la inversión pública española en infraestructuras. Desde que la primera línea se inaugurara en Abril de 1992, la red ferroviaria de alta velocidad se ha visto incrementada ...
Agüeros Sánchez, Manuel, Casares Hontañón, Pedro, Coto Millán, Pablo, San Millán, David   +3 more
core  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

La regulación de inversiones públicas y privadas en territorio indígena: aprendizajes de una experiencia fallida [PDF]

, 2013
En el marco de la política indígena “Re-Conocer: pacto social por la multiculturalidad” (2008) que fijó la agenda que se mantiene hasta hoy entre el Estado y los pueblos indígenas, se realizó un intento poco documentado por crear un marco regulatorio ...
Egaña Barahona, Rodrigo, Molina Monasterios, Sergio   +1 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Desarrollo y Filantropía en el Uruguay Fundaciones: Comunitarias en Uruguay - Recursos locales para el desarrollo [PDF]

, 2012
El presente informe es el resultado de un proceso de investigación desarrollado en el marco del proyecto Fundaciones Comunitarias en Uruguay. Dicho estudio persigue el objetivo de analizar y delinear los perfiles de la filantropía local y profundizar ...
Fabiana Hernández Abreu, Valeria Colombo Sfeir   +1 more
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Body inversion effect in monkeys. [PDF]

PLoS ONE, 2018
Humans visually process human body images depending on the configuration of the parts. However, little is known about whether this function is evolutionarily shared with nonhuman animals.
Toyomi Matsuno, Kazuo Fujita
doaj   +1 more source

De la prosperidad al propósito: Perspectivas sobre la filantropía y la inversión social entre las personas de alto nivel patrimonial en América Latina [PDF]

, 2015
Siglos de tradiciones religiosas, normas culturales, historias políticas y condiciones económicas han moldeado el entorno actual de la filantropía privada y la inversión social en América Latina.
Christine Letts, Colleen Kelly, Paula Doherty Johnson   +2 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source