Results 11 to 20 of about 3,068 (265)

¿Inversiones con violencia o inversiones para la paz?

América Latina Hoy, 2009
RESUMEN: El autor plantea la necesidad de repensar el destino y los objetivos de las inversiones internacionales realizadas durante los últimos años en Colombia. Como indica Modragón, se ha asistido a un desplazamiento de las comunidades indígenas, afroamericanas y de campesinos pobres de los suelos más fértiles, que se ha correspondido con un proceso ...
openaire   +5 more sources

Ro-inversional Spectrum of Ammonia [PDF]

Zeitschrift für Naturforschung A, 1996
The ground state J = 2 ←1 , K = 0 and K = 1 ro-inversional spectrum of 14NH3 and 15NH3 at 1.2 THz has been measured with an accuracy of 20 kHz using the Cologne terahertz spectrometer. The measured frequencies for the K = 0 components are: 14NH3 (J, K) = a(2, 0) - s( 1,0): 1 214 852.942(20) MHz,
G. Winnewisser, S. P. Belov, Th. Klaus, S. Urban   +3 more
openaire   +1 more source

Inmunidad de jurisdicción relativa a la resolución de controversias en materias de inversión ante el CIADI: análisis crítico de la ejecución del laudo Víctor Pey Casado y Fundación Presidente Allende con República de Chile

Revista Justicia y Derecho, 2023
El siguiente artículo se refiere al caso Víctor Pey Casado y Fundación Presidente Allende con República de Chile, el de mayor duración en el sistema CIADI, y que actualmente se encuentra en fase de ejecución ante la justicia española.
Cristián Jara Brito
doaj   +1 more source

Brasil y la nueva generación de Acuerdos de Cooperación y Facilitación de Inversiones: un análisis del Tratado con México

Relaciones Internacionales, 2017
El artículo estudia las cláusulas del Acuerdo de Cooperación y Facilitación de las Inversiones (ACFI) entre Brasil y México en 2015. Se compara con las cláusulas estándar de los Tratados Bilaterales de Inversión (TBI) firmados en los años noventa.
Luciana Ghiotto, Alberto Arroyo Picard
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Turismo de Naturaleza. Complemento por exelencia de los productos de Sol y Playa del Caribe

ARA: Revista de Investigación en Turismo, 2017
Los productos de Turismo de Sol y playa están en plena fase de madurez y, en algunas modalidades y regiones, están mostrando tendencias a la declinación.
Norman Medina, Jorge Santamarina
doaj  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source