Results 51 to 60 of about 455,541 (309)

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

IMPACTS DE L’EMIGRATION MAROCAINE VERS L’ESPAGNE SUR LE DEVELOPPEMENT REGIONAL ET LES TRANSFORMATIONS SOCIO-SPATIALES DANS LA REGION AL HOCEÏMA –TAZA –TAOUNATE (RIF, MAROC SEPTENTRIONAL)

Papeles de Geografí­a, 2001
Esta aportación pretende estudiar y analizar el impacto marroquí hacia España y las transformaciones socio-espaciales en el desarrollo regional del país de origen.
Ali Faleh, Abdelghani Gartet, Oulfa Haj Ali, Amina Hajouj   +3 more
doaj  

Què capgira al cromosoma de la mosca del vinagre? [PDF]

, 2009
Els canvis que afecten l'estructura dels cromosomes són d'una gran importància en l'evolució del genoma eucariota. Un dels canvis estructurals més estudiat és el de les inversions cromosòmiques.
González, Josefa
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

O investimento financeiro em recursos humanos: uma experiência em hospital La inversión financiera en recursos humanos: una experiencia hospitalaria Financial investment in human resources: an experience at a hospital

Revista Latino-Americana de Enfermagem, 2004
Este estudo tem por objetivo levantar o montante financeiro que um hospital de ensino de grande porte investiu nos programas de treinamento. Utilizou-se o sistema de custeio por absorção, para analisar sete programas de treinamentos para funcionários, os
Marli de Carvalho Jericó, Valéria Castilho   +1 more
doaj   +1 more source

Inversiones extranjeras y desarrollo sostenible (una propuesta conciliadora desde el enfoque de justicia relacional) [PDF]

, 2015
Las inversiones extranjeras se canalizan mediante Acuerdos Internacionales de Inversiones -AIIs- (International Investment Agreements -IIAs-) y la inmensa mayoría de ellos son Convenios Bilaterales de Inversiones -CBIs- (Billateral Investment Treaties -
Caro-Gandara, Rocio
core  

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Expectativa y ciclo: hacia una dinámica keynesiana

Cuadernos de Economía, 1991
<p>In chapter 17 of the General Theory, Keynes introduced the concept of the own-rates of interest in order to study a monetary economy of production, under an implicit assumption of equilibrium.
García Molina Mario, García Bolívar Amanda   +1 more
doaj  

Crónica sobre la solución de controversias en materia de inversiones extranjeras (enero-diciembre 2011) [PDF]

, 2012
El artículo pone de relieve los últimos desarrollos en materia de arbitraje sobre inversiones ...
Arp, Björn, Lozano Contreras, Fernando, Pascual Vives, Francisco José, Requena-Casanova, Millan, Vázquez Serrano, Irene   +4 more
core   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source