Results 31 to 40 of about 60,013 (249)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Modulação, Modelagem e Controle do Inversor Boost a Capacitor Chaveado

open access: yesEletrônica de Potência, 2019
O presente artigo analisa um inversor elevador bidirecional de estágio único concebido a partir da integração entre o inversor diferencial boost e células a capacitor chaveado.
Gilberto V. Silva   +3 more
doaj   +1 more source

Notas acerca de la no neutralidad de las condiciones de financiamiento para proyectos de inversión [PDF]

open access: yes, 1999
La posibilidad de contar con financiamiento externo al inversor que pretende desarrollar un proyecto, normalmente genera cambios en los indicadores de rentabilidad. Básicamente es posible identificar dos efectos.
Botteón de Trapé, Claudia Nerina   +1 more
core  

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Estratégias PWM Para Máquina de Indução Hexafásica

open access: yesEletrônica de Potência, 2005
Este artigo investiga o desempenho do acionamento da máquina de indução hexafásica (MIH) utilizando um inversor de seis braços. Três técnicas de modulação PWM vetorial para gerar os sinais de comando de um inversor de seis braços são apresentadas e os ...
Clayton R. da Silva   +3 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Projeto E Desenvolvimento De Um Sistema Inversor Para Fontes De Energia Renovável Com Conectividade À Rede Elétrica

open access: yesEletrônica de Potência, 2007
Este trabalho apresenta um inversor com potência nominal de 1kW, desenvolvido para aplicação em fontes de energia renovável. O equipamento pode operar em dois modos: autônomo ou conectado à rede elétrica com controle do fluxo de potência.
Ruben Barros Godoy   +5 more
doaj   +1 more source

The State of Impact Investing in Latin America [PDF]

open access: yes, 2014
This report lays out an assessment of the current landscape, some of the critical challenges ahead and the likely path forward over the next five 5 to 10 years on impact investing in Latin ...
Andre Leme   +2 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Algunas consideraciones sobre el marco jurídico de protección del inversor en derecho español

open access: yesVia Inveniendi Et Iudicandi, 2016
La protección del inversor y la eficiencia de los mercados de valores son dos principios de política legislativa básicos dentro del Derecho del Mercado de Valores, tal y como se refleja en el artículo 13 de la Ley del Mercado de Valores de 1988.
Maria Valmaña Ochaita
doaj   +1 more source

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