Results 91 to 100 of about 132,267 (326)

Extensive genomic rearrangements mediated by repetitive sequences in plastomes of Medicago and its relatives

BMC Plant Biology, 2021
Background Although plastomes are highly conserved with respect to gene content and order in most photosynthetic angiosperms, extensive genomic rearrangements have been reported in Fabaceae, particularly within the inverted repeat lacking clade (IRLC) of
Shuang Wu, Jinyuan Chen, Ying Li, Ai Liu, Ao Li, Mou Yin, Nawal Shrestha, Jianquan Liu, Guangpeng Ren   +8 more
doaj   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

A clone-free, single molecule map of the domestic cow (Bos taurus) genome. [PDF]

, 2015
BackgroundThe cattle (Bos taurus) genome was originally selected for sequencing due to its economic importance and unique biology as a model organism for understanding other ruminants, or mammals.
Bechner, Michael, Goldstein, Steve, Hernandez-Ortiz, Juan, Medrano, Juan F, Pape, Louise, Patino, Diego, Place, Michael, Potamousis, Konstantinos, Ravindran, Prabu, Rincon, Gonzalo, Schwartz, David C, Zhou, Shiguo   +11 more
core   +1 more source

The complete plastome of Hyacinthoides non-scripta (L.) Chouard ex Rothm. (Asparagaceae) [PDF]

, 2020
The whole plastome sequence ofHyacinthoides non-scripta, was assembled and annotated in this study.This is the first complete plastid genome for the genusHyacinthoides.
Bilsborrow, Jordan, Culham, Alastair, David, John, Garnett, George J. L., Könyves, Kálmán   +4 more
core   +1 more source

Progressive Rearrangement of Telomeric Sequences Added to Both the ITR Ends of the Yeast Linear pGKL Plasmid

Biological Procedures Online, 2003
Relocation into the nucleus of the yeast cytoplasmic linear plasmids was studied using a monitor plasmid pCLU1. In Saccharomyces cerevisiae, the nuclearly-relocated pCLU1 replicated in a linear form (termed pTLU-type plasmid) which carried the host ...
Gunge Norio, Takata Hideki, Matsuura Akira, Fukuda Kohsai   +3 more
doaj   +1 more source

The complete plastome and phylogenetic analysis of Rhoiptelea chiliantha (Juglandaceae)

Mitochondrial DNA. Part B. Resources, 2020
The complete plastome of Rhoiptelea chiliantha was sequenced and assembled in this study. The circular plastome of R. chiliantha is 161,702 bp in size, which contains a large single-copy region (LSC, 90,447 bp), a short single-copy region (SSC, 19,081 bp)
Lei Jin, Guohua Zhou, Mengling He, Zhenyan Yang, Hanjing Yan   +4 more
doaj   +1 more source

DNA sequences of the integration sites and “inverted repeated structure of transposon Tn3

Nucleic Acids Research, 1979
The nucleotide sequence of the "inverted repeat" structure of the transposon Tn3 was determined by the DNA sequencing procedure developed by Maxam and Gilbert(1). The sequence, 38 base pairs long, is as follows: 5'-GGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAG..(Tn3) 3'-CCCCAGACTGCGAGTCACCTTGCTTTTGAGTGCAATTC..
Miyoshi Jun, Tatsuo Takeya, Yasuyuki Takagi, Shimada Kazunori, Hisayuki Nomiyama   +4 more
openaire   +3 more sources

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

Amplification of a transgene within a long array of replication origins favors higher gene expression in animal cells. [PDF]

PLoS ONE, 2017
Plasmids with both a mammalian replication initiation region (IR) and a matrix attachment region (MAR) are spontaneously amplified in transfected cells, and generate extrachromosomal double minute (DM) or chromosomal homogeneously staining region (HSR ...
Kiwamu Ohsaki, Yusuke Ohgaki, Noriaki Shimizu   +2 more
doaj   +1 more source