Results 61 to 70 of about 360,003 (358)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Modelling, Implementation, and Assessment of Virtual Synchronous Generator in Power Systems
Journal of Modern Power Systems and Clean Energy, 2020 As more and more power electronic based generation units are integrated into power systems, the stable operation of power systems has been challenged due to the lack of system inertia. In order to solve this issue, the virtual synchronous generator (VSG),
Meng Chen, Dao Zhou, Frede Blaabjerg
doaj +1 more source
Base drive for paralleled inverter systems [PDF]
, 1980 In a paralleled inverter system, a positive feedback current derived from the total current from all of the modules of the inverter system is applied to the base drive of each of the power transistors of all modules, thereby to provide all modules ...
Nagano, S.
core +1 more source
Low order harmonic cancellation in a grid connected multiple inverter system via current control parameter randomization [PDF]
, 2005 In grid connected multiple inverter systems, it is normal to synchronize the output current of each inverter to the common network voltage. Any current controller deficiencies, which result in low order harmonics, are also synchronized to the common ...
Abeyasekera, T.D. +3 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Analytical Inverter-Based Distributed Generator Model for Power Flow Analysis [PDF]
, 2021 Naeem Turner-Bandele +2 more
openalex +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Grid Tie Inverter in Photovoltaic System for Residential Application [PDF]
, 2010 This paper presents a grid tie inverter (GTI) in photovoltaic, PV system for residential application. The proposed GTI will be switched with a combination switching strategy of square wave and the sinusoidal pulse width modulation, SPWM.
Tan, kheng kwang
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Power loss investigation in HVDC for cascaded H-bridge multilevel inverters (CHB-MLI) [PDF]
, 2015 In the last decade, the use of voltage-source multilevel inverters in industrial and utility power applications has been increased significantly mainly due to the many advantages of multilevel inverters, compared to conventional two level inverters ...
Alamri, B, Darwish, M
core +1 more source