Results 51 to 60 of about 24,034,680 (306)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Research on Fractional Order Controller of Three-Phase Photovoltaic Inverter System Based on Improved Oustaloup Algorithm

IEEE Access
As the core component of photovoltaic grid-connected system, the performance improvement of inverter is an important means to improve the performance of photovoltaic grid-connected system.
Xiaoping Huang, Hongkai Zhou, Wenzhe Huang, Yaqiong Zhang, Pengcheng Wang   +4 more
doaj   +1 more source

Modeling and Analysis of Low-Frequency Oscillation for Electrified Railway under Mixed Operation of Passenger and Freight Trains

Energies, 2022
Addressing the shortcomings of existing low-frequency oscillation research on electrified railways, which has mainly focused on single-type trains and lacks the accurate modeling of traction inverter systems, in this paper we modeled and analyzed low ...
Yunling Wang, Ting Li, Jiawei Liu, Fang Liu, Yunche Su, Qiao Zhang, Weilu Zhang, Zhigang Liu   +7 more
doaj   +1 more source

A cruciform-dumbbell model for inverted dimer formation mediated by inverted repeats [PDF]

Nucleic Acids Research, 1997
Small inverted repeats (small palindromes) on plasmids have been shown to mediate a recombinational rearrangement event in Escherichia coli leading to the formation of inverted dimers (giant palindromes). This recombinational rearrangement event is efficient and independent of RecA and RecBCD.
C T, Lin, Y L, Lyu, L F, Liu
openaire   +2 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

An Anti-Islanding Protection for VSM Inverters in Distributed Generation

IEEE Open Journal of Power Electronics, 2020
Virtual synchronous machine (VSM) technology is an attractive control method for an inverter-based distributed generation (DG) due to having the voltage, and frequency support functionality. Embedding an anti-islanding protection (AIP) scheme with a high
Mohammad Amin, Qing-Chang Zhong, Zijun Lyu   +2 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Stability of input voltages of a three-level inverter NPC fed by photovoltaic sources

Revue des Énergies Renouvelables, 2012
In this paper we study the stability of input voltages of the cascade consisting of a photovoltaic inverter and a three-level structure NPC, feeding a synchronous machine with permanent magnets (PMSM) commissioned by the speed command flow oriented.
F. Bouchafaa, A. Chouder, S. Boukhalfa   +2 more
doaj