Results 31 to 40 of about 6,761 (247)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

A Hybrid Commutation Technique for Reducing Zero-Crossing Distortion in a Sliding Mode Controller for Single-Phase Grid-Tied Full-Bridge Inverters

Energies
This paper presents a single-phase Full-Bridge (FB) inverter with a hybrid commutation technique designed to reduce the harmonic distortion caused by the loss of the controller capability around the zero-crossing point in the unipolar commutation region.
Mario Andrés Bolaños-Navarrete, Juan David Bastidas-Rodríguez, Gustavo Osorio   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Graph Invertibility

Graphs and Combinatorics, 2013
Extending the work of Godsil and others, we investigate the notion of the inverse of a graph (specifically, of bipartite graphs with a unique perfect matching). We provide a concise necessary and sufficient condition for the invertibility of such graphs and generalize the notion of invertibility to multigraphs.
McLeman, Cam, McNicholas, Erin
openaire   +3 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Facilitating the Transition to an Inverter Dominated Power System: Experimental Evaluation of a Non-Intrusive Add-On Predictive Controller

Energies, 2020
The transition to an inverter-dominated power system is expected with the large-scale integration of distributed energy resources (DER). To improve the dynamic response of DERs already installed within such a system, a non-intrusive add-on controller ...
Mazheruddin H. Syed, Efren Guillo-Sansano, Ali Mehrizi-Sani, Graeme M. Burt   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Comprehensive Review and State of Development of Double-Sided Cooled Package Technology for Automotive Power Modules

IEEE Open Journal of Power Electronics, 2022
Power modules are core components of inverters in electric vehicles and their packaging technology has a critical impact on system performance and reliability.
Ming Liu, Anthony Coppola, Muhammad Alvi, Mohammad Anwar   +3 more
doaj   +1 more source