Results 101 to 110 of about 2,103,421 (365)

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Where should governments invest their research funding? [PDF]

Anyone observing the world in which they live can see how the outputs of research improve our life, work and environment. Some people believe that if governments invest specifically in research designed to produce immediately useful outcomes, it could ...

core  

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Scenario modelling to predict future changes in land cover and/or land use, using InVEST software (case study: Dohezar and Sehezar forested landscape) [PDF]

علوم محیطی, 2018
Introduction: Changes in land use and/or land cover (LULC) are associated with many socio-economic and physical environmental factors. Due to the multiplicity and diversity of variables involved and drivers that cause changes, the prediction of future ...
َArdavan Zarandian, Roya Mousazadeh, Jalil Badamfirooz, Alireza Rahmati   +3 more
doaj  

Relationships of Habitat Quality to Characteristics of Soil, Topography, and Landscape Features Across Qeshlagh Dam Watershed in Western Iran [PDF]

Sustainable Earth Trends
This research investigates the relationships between habitat quality, soil characteristics, topography and landscape metrics across soil zones and sub-basins of the Qeshlagh dam in western Iran.
Kazhan Hasani, Bubak Souri, Fazlolah Ahmadi Mirghaed   +2 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

To Invest Or Not Invest? : Factors affecting IT investment decisions

, 2009
  Introduction Many studies indicate that there are numerous factors that promote or hamper the adoption of IT applications and are a prime concern for many researchers and practitioners (Abrahamson, 1991). Two main factors which need to be examined closely when making decisions about IT investments are the internal and external factors.
Tarabay, Raymond, Eigbire, Raphael
openaire   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Opzioni reali e Investimenti in Ricerca e Sviluppo [PDF]

This paper combines the real options approach with game theory in order to evaluate the convenience to invest in Research and Development (R&D). The evaluation method adopted in this case is not based on the traditional $VAN$ but on the binomial model ...
Rosalba Padalino
core  

To invest or not to invest the business Angel´s dilemma

Journal of Innovation & Knowledge
Business Angels (BAs) are pivotal in early-stage funding for entrepreneurship. This study explores the factors influencing BA investment decisions. We propose a theoretical model based on signaling theory to assess the impact of signals about the quality of entrepreneurs and projects on investment assessments and decisions.
Oscar Arroyo-Revilla, Cayetano Medina-Molina, Carlos Bellón Núñez-Mera, Noemí Pérez-Macías   +3 more
openaire   +3 more sources