Results 141 to 150 of about 23,565,951 (358)

Optimal asset allocation for aggregated defined benefit pension funds with stochastic interest rates [PDF]

, 2008
In this paper we study the optimal management of an aggregated pension fund of defined benefit type, in the presence of a stochastic interest rate. We suppose that the sponsor can invest in a savings account, in a risky stock and in a bond, with the ...
Josa-Fombellida, Ricardo, Rincón-Zapatero, Juan Pablo   +1 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Contract Damages and Investment Dynamics [PDF]

The present article provides an economic analysis to examine how contract damages affects both breach and investment decisions over time. Unlike the standard static model, this article studies a model in which, upon signing a contract, a seller invests ...
Alan Chan, Tai-Yeong Chung
core  

Real‐World Performance of CSF Kappa Free Light Chains in the 2024 McDonald Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Kappa free light chains (KFLCs) in the cerebrospinal fluid (CSF) have a similar performance to CSF‐restricted oligoclonal bands (OCB) for multiple sclerosis (MS) diagnosis. To help with implementation, we set out to resolve several remaining uncertainties: (1) performance in a real‐world cohort and the 2024 McDonald criteria; (2 ...
Maya M. Leibowitz, Ryan Cooper, Stefania Kaninia, Kathryn I. Challis, Will Greenway, Maria Bonello, Mahmoud Elbahnasawi, Deborah T. Shode, Dominika Gajdasik, Victor Iliev, Alison M. E. Whitelegg, Ian Galea   +11 more
wiley   +1 more source

Biased Social Learning [PDF]

This paper examines social learning when only one of the two types of decisions is observable. Because agents arrive randomly over time, and only those who invest are observed, later agents face a more complicated inference problem than in the standard ...
Helios Herrera, Johannes Horner
core  

Applying an Ethical Lens to the Treatment of People With Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The practice of neurology requires an understanding of clinical ethics for decision‐making. In multiple sclerosis (MS) care, there are a wide range of ethical considerations that may arise. These involve shared decision‐making around selection of a disease‐modifying therapy (DMT), risks and benefits of well‐studied medications in comparison to
Methma Udawatta, Farrah J. Mateen
wiley   +1 more source

Spatial-temporal evolution of habitat quality in tropical monsoon climate region based on “pattern–process–quality” – a case study of Cambodia

Open Geosciences
Exploring the coupling relationship of “pattern–process–quality” is conducive to understanding the internal mechanism of habitat quality change, and is of great significance for the function maintenance and sustainable management of regional ecosystems ...
Kang Junmei, Yang Fengshuo, Wang Jun, Liu Yang, Fang Dengmao, Jiang Chengcheng   +5 more
doaj   +1 more source

Traumatic Microhemorrhages Are Not Synonymous With Axonal Injury

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diffuse axonal injury (DAI) is caused by acceleration‐deceleration forces during trauma that shear white matter tracts. Susceptibility‐weighted MRI (SWI) identifies microbleeds that are considered the radiologic hallmark of DAI and are used in clinical prognostication.
Karinn Sytsma, Rhonda Mittenzwei, Heather Maioli, Amanda Kirkland, C. Dirk Keene, Ramon Diaz‐Arrastia, Christine Mac Donald, Chiara Maffei, Brian L. Edlow, Amber L. Nolan   +9 more
wiley   +1 more source

Spatio-Temporal Evolution and Prediction of Carbon Storage in the Water Conservation Area of the Yellow River Basin based on the PLUS-InVEST Model

Gaoyuan qixiang
Climate and land-use change are important drivers of variation in carbon storage within terrestrial ecosystems.Investigating the effects of climate and land-use change on carbon storage has practical implications for proposing adaptive management ...
Wei ZHANG, Rui ZHU, Huaqing YANG, Jian’an SHAN, Yonglin FENG, Zhenliang YIN   +5 more
doaj   +1 more source