Results 311 to 320 of about 4,895,980 (389)
Advanced Science, EarlyView.This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen +11 more
wiley +1 more source
A new species of <i>Thibaudia</i> (Ericaceae, Vaccinieae) from the Cordillera del Cóndor in Ecuador. [PDF]
Biodivers Data JJiménez MM +6 more
europepmc +1 more source
Advanced Science, EarlyView.This study extensively characterizes the B cell response of rainbow trout (Oncorhynchus mykiss) in response to red mark syndrome (RMS). This disease, suspected to be caused by a Midichloria‐like organism (MLO), induces skin lesions in the infected animals, characterized by a massive influx of IgM+ B cells.
J Germán Herranz‐Jusdado +10 more
wiley +1 more source
Annotated dataset of simulated voiding sound for urine flow estimation. [PDF]
Sci DataAlvarez ML +3 more
europepmc +1 more source
La sociología y la investigación social
, 1970 Lucio Mendieta y Núñez +1 more
openalex +2 more sources
A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain
Advanced Science, EarlyView.Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria +5 more
wiley +1 more source
RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics
Advanced Science, EarlyView.RAB5A‐mediated unjamming enhances active wetting through distinct biomechanical processes: a) upregulation of specific integrin subunits, enhanced focal adhesions kinetics and activity; b) supracellular organization relying on nanoscale integrin clustering, and the formation of a stiff and collective actin cable; and c) softening of the spheroid core ...
Grégoire Lemahieu +19 more
wiley +1 more source
Evaluating Liquid Biopsy for Circulating Tumor DNA (ctDNA) Detection as a Complementary Diagnostic Tool in Thyroid Cancer Among Ecuadorian Women. [PDF]
Int J Mol SciCadena-Ullauri S +13 more
europepmc +1 more source