Results 171 to 180 of about 4,211,479 (248)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

ADA2 genotype and enzyme activity may predict vasculitic or hematologic DADA2 phenotype. [PDF]

J Hum Immun
Peters P, Schepp J, Albert MH, von Bernuth H, Blank N, Brunner J, Dückers G, Ehlers L, Farmand S, Föll D, Förster-Waldl E, Gburek-Augustat J, Ghosh S, Göschl L, Hömberg M, Hönig M, Kallinich T, Klemann C, Klingel L, Kontny U, Kuhn LM, Lamprecht P, Lehmberg K, Meyer-Bahlburg A, Müller I, Nathrath M, Niehues T, Oommen PT, Pachlopnik Schmid J, Prader S, Puzik A, Renella R, Schulz A, Skrabl-Baumgartner A, Starke S, Tarrant TK, Hershfield M, Grimbacher B, Hauck F.   +38 more
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Verification of the value of optimization of the medication-related clinical decision support system in China, a hospital-based study. [PDF]

JAMIA Open
Ran S, Gu D, Xie J, Jiang K, Yao N, Fang Z, Asakawa T, Zhang N, Fang H.   +8 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

High inappropriate red blood cell transfusion rate despite low overall use: a real-world multicenter study in 43 Spanish hospitals. [PDF]

Front Med (Lausanne)
Tamayo-Velasco Á, Llau JV, Colomina MJ, de la Varga-Martínez O, Navarro-Pérez R, López-Herrero R, Almoguera-Fernández J, Alonso-Fernández M, Artiaga-Candia M, Becerra-Bolaños Á, Bugueño N, Casasempere-Sanus A, Contreras-López L, Heredia-Rodríguez M, de la Fuente-Graciani I, de la Rosa-Estadella M, de la Torre-Riveiro I, Del Val-Peciña E, Delgado-Martí C, Edo-Cebollada L, Fernández-Fernández R, Fernández-Rodríguez J, Ferrer-Gómez C, Giné-Servén M, González-Pereira A, Guereca-Gala A, Herrera-Soto A, Infantes-Morales ME, Marcos-Vidal JM, Illodo-Miramontes G, Martínez-López A, Martínez-Ruiz A, Martínez-Rafael B, Matute-González A, Pariente-Juste L, Pérez-González S, Gómez-Pesquera E, Renedo-Fernández A, Rodríguez-Álvarez AA, Sánchez-Rodríguez I, Del Aranzazú Rodríguez-Conesa M, Sánchez-González C, Tobar-Gonzalo C, Varela-Rodríguez L, Veloso-de Sousa R, Muñoz-Moreno MF, García-Sánchez JI, Rocha-García F, González-Montes P, Cid-Boo P, Escudero-Gómez G, Romero-García N, Cots A, Peñarrubia-Ponce MJ, Hornero R, Santamaría-Vázquez E, Poves-Álvarez R, Tamayo E, Varela-Duran M, Badenes R, DELPO Study Group.   +60 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Perspective: can interfacial defects enhance graphene's reactivity for gas-surface reactions under ultra-high vacuum? [PDF]

Front Chem
Seif A, Stach T, Pham TT, Uddin MA, Colomer JF, Sporken R, Ambrosetti A, Silvestrelli PL, Burghaus U.   +8 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source