Results 221 to 230 of about 12,004,584 (291)

2012 maladministration investigation procedures [PDF]

, 2012

core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

From methods to policy: a critical appraisal of the 2024 ECDC guidance on enhanced influenza vaccines. [PDF]

Front Public Health
Ortiz de Lejarazu R, Ocaña D, Arrazola P, Orrico-Sánchez A, Redondo E, Sanz-Muñoz I, Tolosa N, Trilla A.   +7 more
europepmc   +1 more source

Investigative Body without Investigation

CRIMINAL-EXECUTORY SYSTEM: LAW, ECONOMICS, MANAGEMENT, 2018
openaire   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Chorea-acanthocytosis presenting with epilepsy at onset harboring novel compound heterozygous <i>VPS13A</i> mutations. [PDF]

Clin Park Relat Disord
Tamura M, Furukawa S, Namiki M, Ozawa Y, Urata Y, Nakamura M, Watanabe M, Oshima H, Obuchi T, Ichikawa T, Kikkawa Y.   +10 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Educational attainment is associated with reduced functional decline in Puerto Ricans with elevated pTau181. [PDF]

J Alzheimers Dis
Dorfsman DA, Cai D, Hamilton-Nelson KL, Adams LD, Mena PR, Rodriguez VC, Sanchez JJ, Valladares GS, Lopez M, Whitehead PL, Prough MB, Manrique P, Martinez A, Mas SM, Scaramutti C, Acosta H, Silva-Vergara C, McInerney K, Griswold AJ, Feliciano-Astacio BE, Cuccaro ML, Kunkle BW, Reitz C, Tosto G, Bush WS, Haines JL, Akinyemi JO, Akinyemi RO, Ogunniyi A, Byrd GS, Vance JM, Celis K, Seixas A, Pericak-Vance MA, Rajabli F.   +34 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

TRPtracker: a community database for monitoring praziquantel sensitivity at TRPM_PZQ variants. [PDF]

Int J Parasitol Drugs Drug Resist
Rohr CM, Park SK, Aguiar-Martins K, Anderson TJC, Berger DJ, Berriman M, Buddenborg SK, Bustinduy AL, Chevalier FD, Cotton JA, Crellen T, Doyle SR, Emery AM, Kincaid Smith J, Kinung'hi S, Lamberton PHL, Le Clec'h W, Ndombi E, Pennance T, Rowel C, Summers SS, Tushabe JV, Walker M, Webster BL, Webster JP, Wilson S, Marchant JS.   +26 more
europepmc   +1 more source