Results 61 to 70 of about 3,853,799 (198)

Deep Phenotyping of F64L Mutation in a Multicentric Cohort of Patisiran-Treated Hereditary Transthyretin Amyloidosis Patients (Patisiranitaly). [PDF]

Eur J Neurol
Ceccanti M, Guaraldi P, Romano A, Antonini G, Barilaro A, Briani C, Burattini M, Gianoli M, Carlini G, Cianci V, Dossi MC, Di Lisi D, Di Muzio A, Ratti A, Filosto M, Gasverde S, Gemelli C, Gentile L, Goglia M, Leonardi L, Longhi S, Lotti A, Manganelli F, Mazzeo A, Augello SM, Milella G, Novo G, Pareyson D, Fenu S, Palumbo G, Petrelli C, Poli L, Pradotto LG, Russo M, Salvalaggio A, Sciarrone MA, Sellitti L, Tagliapietra M, Tozza S, Castiglia M, Turri M, Verriello L, Chimenti C, Vitali F, Brighina F, Rini N, Inghilleri M, D'Angelo R, Abelardo D, Cambieri C, Libonati L, Moret F, Luigetti M, Di Stefano V.   +53 more
europepmc   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Efficacy of MAPK inhibitors in children with neurodegenerative Langerhans cell histiocytosis: Results from the European Consortium for Histiocytosis. [PDF]

Hemasphere
Pegoraro F, Chalard F, Evseev D, Barkaoui M, Le Louet S, Thalhammer J, Aladjidi N, Salmon A, Marec-Berard P, Gaspari S, De Fusco C, Trambusti I, Verrico A, Raciborska A, Svojgr K, Křenová Z, Slater O, Millen G, Ben Arush M, Ashkenazi Lustig D, Von Bahr Greenwood T, Hutter C, Astigarraga I, López-Duarte M, Valero-Arrese L, Ortega Acosta MJ, van den Bos C, Naeije L, Martin-Munoz D, Perrone A, Mortilla M, Felician O, Idbaih A, Héritier S, Nanduri V, Minkov M, Henter JI, Sieni E, Donadieu J.   +38 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Statins enhance trastuzumab deruxtecan efficacy: preclinical synergy in HER2-negative models and clinical benefit in HER2-positive metastatic breast cancer. [PDF]

Exp Hematol Oncol
Sahin TK, Orhan C, Ozercan IH, Muglu H, Er B, Akyildiz A, Tunbekici S, Oruc A, Aykan MB, Koylu B, Akdogan O, Onur ID, Ates O, Yazici O, Selcukbiricik F, Karadurmus N, Araz M, Erdem D, Goker E, Bilici A, Aksoy S, Guven DC.   +21 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

<i>SHLD2</i> loss is a synthetic vulnerability to Polθ inhibition combined with radiotherapy. [PDF]

Sci Adv
Rodriguez-Berriguete G, Thambiayah P, Cicconi A, Machado N, Gotorbe C, Nderitu D, Cheng WC, Fowler G, Boursier ML, Cerutti A, Grinkevich V, Hill BR, Koler K, Langdon SA, Majithiya JB, Menon S, Moore S, Neves J, Palmer-Deverill NM, Rajendra E, Roy-Luzarraga M, Thapa A, Heald RA, Smith GCM, Robinson HMR, Ranzani M, Higgins GS.   +26 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source