Results 181 to 190 of about 18,913,418 (345)

Setting the standard: empirical benchmarks for case-level site-central discordance in radiographic endpoints in oncology clinical trials. [PDF]

Contemp Clin Trials Commun
Goldmacher GV, Goldberg CM, Boyle L, Jia L, Gause CK, Green MC, Schwartz LH.   +6 more
europepmc   +1 more source

The Confidence Database Investigator Adjunct Investigator Adjunct Investigator

Understanding how people rate their confidence is critical for characterizing a wide range of perceptual, memory, motor, and cognitive processes. However, as in many other fields, progress has been slowed by the difficulty of collecting new data and the unavailability of existing data.
Dobromir Rahnev, Kobe Desender, Alan L. F. Lee, William T. Adler, David Aguilar-Lleyda, Başak Akdoğan, Polina Arbuzova, Lauren Atlas, Fuat Balcı, Ji Won Bang   +9 more
openaire   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Artificial intelligence-assisted reinterpretation of preclinical progeria research suggests a hierarchical nuclear-vascular resilience framework with translational implications. [PDF]

Int J Biol Sci
Madeddu P, Cattaneo M, Puca AA.
europepmc   +1 more source

INVESTIGATING HYPERTENSION [PDF]

The Lancet, 1967
openaire   +4 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

A Silver-Zeolite Spray Powder for Pressure Ulcers and Minor Burns: Real-World Evidence from Primary Care. [PDF]

Med Devices (Auckl)
Mureșan L, Barattini DF, Ianoși LS, Signorini C, Harb R.   +4 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The challenge of investigator

, 2016
У статті досліджено порядок заявлення та вирішення відводу, самовідводу слідчого в кримінальному прова- дженні, проаналізовано наукові підходи щодо процедури заявлення відводу, самовідводу слідчого.
Денісова, Г.В., Дем’янчук, В.А,   +1 more
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