Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Datopotamab deruxtecan versus chemotherapy in previously treated inoperable/metastatic hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer: results from the TROPION-Breast01 China cohort. [PDF]
Wang S +23 more
europepmc +1 more source
Nurse scientist and advanced practice registered nurse contributions to oncology clinical trials within the National Cancer Institute Cooperative Group infrastructure. [PDF]
Myers JS.
europepmc +1 more source
Efficacy and safety of botulinum toxin type a for upper-limb essential tremor: a systematic review and meta-analysis of randomized placebo-controlled trials. [PDF]
Wang G, Cheng L, Liao Z.
europepmc +1 more source
Apatinib monotherapy for pretreated advanced squamous cell carcinoma of the penis: a phase 2 trial. [PDF]
Zhou J, Li W, Sun M, Zhang S.
europepmc +1 more source
[Editorial: Investigation--investigators].
openaire +1 more source

