Results 71 to 80 of about 7,374 (204)

Unraveling G‐Quadruplex and i‐Motif Coexistence Within a Double‐Stranded DNA

open access: yesAngewandte Chemie, Volume 138, Issue 31, 27 July 2026.
The relative thermodynamic profiles of G‐quadruplex (G4), i‐Motif (iM), and the duplex counterpart tune the simultaneous G4 and iM formation within a double‐stranded (ds) DNA. ABSTRACT DNA can transiently fold into variable arrangements, which are expected to exploit regulatory functions. Guanine‐rich sequences can fold into G‐quadruplexes (G4s), while
Davide Auricchio   +7 more
wiley   +2 more sources

Unveiling the molecular profile of adenosquamous gallbladder carcinoma: characterization of a Caucasian cohort

open access: yesHistopathology, Volume 89, Issue 3, Page 442-455, September 2026.
GBASCs are MMRp tumours, exhibiting minimal HER2 overexpression and elevated PD‐L1 expression compared to adenocarcinomas. Especially in metastatic and TP53‐wild type tumours, GBASCs can express CLDN18, albeit limited to the glandular component. Their genomic profile resembles that of adenocarcinomas with an enrichment in alterations on PIK3CA, PTEN ...
Jessica Gasparello   +20 more
wiley   +1 more source

New Polymeric Binders for the Preparation and Optimization of Pt/C‐Based Electrodes for Proton‐Exchange Membrane Fuel Cells (PEMFCs)

open access: yesChemElectroChem, Volume 13, Issue 16, 18 August 2026.
This study optimizes PEMFC catalyst layers (CLs) by comparing short‐side‐chain N+125D and high‐oxygen‐permeability EIG ionomers. By analyzing ionomer–solvent interactions in water/1‐propanol mixtures through advanced physical–chemical characterization, the research ensures ink stability and homogeneous electrocatalyst distribution.
Christian Dall’Occo   +5 more
wiley   +1 more source

Exploring Disulfide Bridge as a Tool to Improve Pioglitazone’s Neuroprotective Potential: Toward the Development of Prolonged‐Acting MAO‐B/PPARγ Modulators

open access: yesChemMedChem, Volume 21, Issue 15, 14 August 2026.
Pioglitazone is an antidiabetic drug acting as a peroxisome proliferator‐activated receptor γ (PPARγ) agonist and later repositioned as a monoamine oxidase B (MAO‐B) inhibitor. Despite promising preclinical premises, it showed a lack of efficacy in clinical trials as a treatment for neurodegenerative diseases.
Filippo Basagni   +12 more
wiley   +1 more source

Investimento e financiamento: um enfoque sobre empresas de capital aberto

open access: yesRevista de Economia Contemporânea, 2011
O objetivo do artigo é analisar os determinantes do investimento para uma amostra com 334 empresas no Brasil para o período de 1998 a 2000. As empresas foram selecionadas segundo o critério de liquidez acionário através do índice de negociabilidade de ...
Elton Eustáquio Casagrande   +1 more
doaj   +1 more source

Biocatalytic Application of Goodfellowiella coeruleoviolacea Imine Reductase: Enantioselective Synthesis of Cyclic Secondary Amines in Deep Eutectic Solvent‐Based Media

open access: yesAdvanced Synthesis &Catalysis, Volume 368, Issue 15, 1 August 2026.
A Goodfellowiella coeruleoviolacea Imine Reductase is here reported as a novel enzyme for biocatalytic application in chiral amine synthesis. Deep eutectic solvents have been used to increase substrate loadings, up to 150 mM, and boost enzymatic activity. Reaction scope and scale‐up procedure showcased the protocol applicability.
Federica De Nardi   +5 more
wiley   +1 more source

One‐Shot Multimaterial 3D Printing of a Flexible Spine for a Robotic Fish Prototype

open access: yesAdvanced Intelligent Systems, Volume 8, Issue 8, August 2026.
A one‐shot multimaterial 3D printing approach enables a monolithic soft robotic fish integrating a compliant spine and rigid vertebrae. Electromagnetic linear actuators drive tendon‐based transmission, producing controlled tail oscillations. Finite element modeling and experiments show strong agreement, while optimized material selection improves ...
Marco Colletta   +3 more
wiley   +1 more source

Deverão os investimentos em imóveis ser considerados investimentos financeiros

open access: yes, 2005
A problemática em torno da classificação dos activos de longa duração cuja utilização não esteja directamente ligada à exploração da empresa tem gerado algumas iniquidades que, a nosso ver, encontram todo o sentido na formulação que o Plano Oficial de Contabilidade (POC), nas suas notas `conta 414 “Investimentos Financeiros – Investimentos em Imóveis”,
Pires, Amélia M.M.   +1 more
openaire   +1 more source

Two Closely Related Butterflies Show Pseudo‐Concordant Patterns of Geographic Differentiation in a Heterogeneous Mountain Region

open access: yesEcology and Evolution, Volume 16, Issue 8, August 2026.
Phylogeographic pseudo‐concordance among species—coincident spatial structuring coupled with differing levels of intraspecific differentiation—has rarely been documented in heterogeneous regions. We report a clear case in two mountain butterfly species and show how the high density of spatial sampling and the integration of phenotypic and genomic ...
Luca Gregnanin   +6 more
wiley   +1 more source

The hunt for Scabiosa trenta Hacq: how the pursuit of a phantom ignited a passion for botany and mountaineering

open access: yesNordic Journal of Botany, Volume 2026, Issue 8, August 2026.
Scabiosa trenta Hacq. was first described in 1782 by Balthasar Hacquet, with its specific epithet referring to the Trenta Valley in Slovenia. Since then, S. trenta has been the focus of numerous mountaineering and botanical expeditions, particularly by the alpinist Julius Kugy during the Golden Age of Alpinism, a period in the second half of 19th ...
Valentina Boscariol   +5 more
wiley   +1 more source

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