Results 41 to 50 of about 23,093,389 (299)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

HEURISTIC ANALYSIS OF INVESTMENT STRATEGY

open access: yesTechnological and Economic Development of Economy, 2006
The present article investigates the problem of optimal investment, when, given a limited amount of funds, a decision must be taken to which projects and what amounts of funds are to be invested. Supposing that the expected average profit depends on several possible different market conditions, a matrix .game against nature.
Vakrinienė, Sigutė   +1 more
openaire   +4 more sources

Global Investment Promotion Best Practices 2012 : Seizing the Potential for Better Investment Facilitation in the MENA Region

open access: yes, 2013
The drop in foreign direct investment (FDI) flows to the Middle East and North Africa (MENA) region over the past three to four years stems in part from the aftermath of the recent global economic crisis, and in
Multilateral Investment Guarantee Agency   +2 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Introduction to Foreign Direct Investment System in Korea 2003.7

open access: yes, 2003
I. Overview 1. Definition 2. FDI-related laws (Related laws, Foreign investment Promotion Act) 3. FDI protection 4. FDI-allowed businesses II. FDI procedures 1. FDI through acquisition of newly issued stocks 2.

core   +1 more source

SPECIFICS OF USING THE CAMELS ESTIMATION METHOD FOR CALCULATING THE INVESTMENT ATTRACTIVENESS OF A COMMERCIAL BANK ON THE EXAMPLE OF VTB BANK PJSC

open access: yesВестник Северо-Кавказского федерального университета, 2022
This paper examines the CAMELS rating system, which is currently used by Central Banks in developed countries. In our country, it is adaptedfor calculating the investment attractiveness of commercial banks.
E. Adamov, A. Fedorova, O. Chernyshova
doaj  

Co-Movement and Performance Comparison of Conventional and Islamic Stock Indices during the Pre- and Post-COVID-19 Pandemic Era

open access: yesRisks, 2023
This study conducts a comparative analysis of the performance of Islamic and conventional indices in both developed and developing countries and territories, considering the pre- and post-COVID-19 pandemic periods.
Muhammad Alamgir, Ming-Chang Cheng
doaj   +1 more source

Risk analysis in investment appraisal [PDF]

open access: yesProject Appraisal, 1994
This paper was prepared for the purpose of presenting the methodology and uses of the Monte Carlo simulation technique as applied in the evaluation of investment projects to analyse and assess risk. The first part of the paper highlights the importance of risk analysis in investment appraisal.
openaire   +3 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

EIB Working Papers 2019/08 - Investment

open access: yes, 2019
In Romania, the share of firms carrying out investment is amongst the lowest in the European Union. This is despite strong economic growth in recent years and persistent needs for upgrading the capital stock in the country.
Stamate, Amalia   +4 more
core   +1 more source

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