Results 41 to 50 of about 2,551,240 (307)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Modelling of net flows to investment funds

open access: yesJournal of Business Economics and Management, 2003
The paper presents the general model of net flows to investment funds, which helps to analyse the flows and to solve the problem structurally. The model includes various investment guidelines and different fund types, aspects of risk influence are ...
Leonas Simanauskas   +2 more
doaj   +1 more source

Express evaluation methods for creating small and medium business projects

open access: yesπ-Economy, 2022
In this study the authors analyzed the problems associated with organizing private business and startup project appraisal for public and private funding.
Stepanchuk Andrey, Burova Ekaterina
doaj   +1 more source

Investment Analysis of New Inpatient Wards Project at Ulin Hospital of Banjarmasin [PDF]

open access: yes, 2013
Adequate health care in a province is one of the primary needs that cannot be neglected. These needs will affect the health and life expectancy of the population of the province.
Aliludin, A. (Arson)   +1 more
core  

Which projects are selected for an innovation subsidy? The Portuguese case [PDF]

open access: yes, 2019
Several empirical studies have analyzed which firm characteristics influence government evaluators in the decision to select specific firms to participate in Research and Develop- ment and Innovation subsidy programs. However, few authors have provided a
Cincera, Michele   +3 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

An Options Approach to Cybersecurity Investment

open access: yesIEEE Access, 2018
Cybersecurity has become a key factor that determines the success or failure of companies that rely on information systems. Therefore, investment in cybersecurity is an important financial and operational decision.
Michail Chronopoulos   +2 more
doaj   +1 more source

Data Envelopment Analysis Models of Investment Funds [PDF]

open access: yes, 2010
Publisher ...
Lamb, John Douglas, Tee, Kai-Hong
core  

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