Results 51 to 60 of about 9,737,718 (254)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

EIB Working Papers 2019/08 - Investment

, 2019
In Romania, the share of firms carrying out investment is amongst the lowest in the European Union. This is despite strong economic growth in recent years and persistent needs for upgrading the capital stock in the country.
Stamate, Amalia, Wruuck, Patricia, Pal, Rozalia, Catalin Dumitrescu, Constantin, Dumitrescu, Constantin Catalin   +4 more
core   +1 more source

Introduction to Foreign Direct Investment System in Korea 2003.7

, 2003
I. Overview 1. Definition 2. FDI-related laws (Related laws, Foreign investment Promotion Act) 3. FDI protection 4. FDI-allowed businesses II. FDI procedures 1. FDI through acquisition of newly issued stocks 2.

core   +1 more source

ECONOMIC ESSENCE OF MODERN INVESTMENT PROCESSES IN THE GRAIN PROCESSING INDUSTRY

Baltic Journal of Economic Studies, 2015
The subject of the research is theoretical and methodological bases of formation of effective investment in priorities feed processing industry in Ukraine.
Inna Kanashkina
doaj  

Theoretical and Methodological Foundations of Designing a balance Model for Reproducing Investment Potential of Institutional Sectors in the Regional System

Финансы: теория и практика, 2019
Reproducing investment potential of institutional sectors of the economy of any territorial system becomes a challenging issue in the light of recent trends: lack of financial resources for modernization and development of the real sector of economy ...
I. V. Naumov
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

INCREASING THE REGIONAL INVESTMENT ATTRACTION BY PREPARING AND HOLDING OF LARGE SPORTS EVENTS

Russian Journal of Economics and Law, 2012
The work is devoted to the study of the regional investment attraction factors, as well as grounding the modern techniques of its increasing by holding large sports events of international scale by the example of Universiade 2013 in Kazan.
V. A. Leonov
doaj  

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

World Investment and Political Risk 2009

, 2009
Political risk is a top concern for corporate foreign investors from industrialized but also developing countries when venturing into emerging markets. At the same time, these investors maintain a positive
Multilateral Investment Guarantee Agency
core   +1 more source