Results 251 to 260 of about 39,988 (308)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

HR-Mamba: Building Footprint Segmentation with Geometry-Driven Boundary Regularization. [PDF]

Sensors (Basel)
Su B, Yin D, Yi P, Wu W, Liu J, Yang F, Mu H, Xiong J.   +7 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Aging diminishes thymic output, reduces naive T cells, promotes memory T-cell accumulation, and impairs thymic regeneration. [PDF]

Am J Physiol Regul Integr Comp Physiol
Konovalova DM, Cooper MD, Huang S, Shane DX, Mulhern JS, Chiao YA, Yuan SY, Ma Y.   +7 more
europepmc   +1 more source

Morphometric analysis of the thymic epithelial cell network using integrated and orthogonal digital pathology approaches. [PDF]

Commun Biol
Lagou MK, Markaki MP, Vodopyanov S, Argyris DG, Karagiorgis GK, Gunther-Cummins L, Hardas A, Panorias C, DesMarais S, Entenberg C, Carpenter RS, Filippou PS, Guzik H, Nishku X, Churaman J, DesMarais V, Macaluso FP, Maryanovich M, Angelopoulou K, Poutahidis T, Karagiannis GS.   +20 more
europepmc   +1 more source

Dynamic kernel generation through hybrid involution and convolution neural networks for leukemia and white blood cell classification. [PDF]

Sci Rep
Alshehri OM, Shaf A, Shakeel U, Ali T, Irfan M, Jalal MM, Altayar MA, Abu-Alghayth MH, Shmrany HA.   +8 more
europepmc   +1 more source

Imaging Strategies for Pediatric Neck Lesions: A Contemporary Review. [PDF]

J Korean Soc Radiol
Park JE.
europepmc   +1 more source

Therapy-resistant pretibial myxedema addressed with intralesional hyaluronidase. [PDF]

JAAD Case Rep
Gregersen DM, Darr-Foit S, Tittelbach J.
europepmc   +1 more source

Turning the clock: mRNA-encoded thymic factors restore aged immunity. [PDF]

Signal Transduct Target Ther
Khan MN, Li H, Li X.
europepmc   +1 more source