Results 151 to 160 of about 22,596 (283)

Quantum Walks: Schur Functions Meet Symmetry Protected Topological Phases. [PDF]

Commun Math Phys, 2022
Cedzich C, Geib T, Grünbaum FA, Velázquez L, Werner AH, Werner RF.   +5 more
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

A Unifying Framework for Complex-Valued Eigenfunctions via The Cartan Embedding. [PDF]

J Geom Anal
Gudmundsson S, Lindström A.
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Classification of prime modules of quantum affine algebras corresponding to 2-column tableaux. [PDF]

J Algebr Comb (Dordr)
Early N, Li JR.
europepmc   +1 more source

Nuclear degradation dynamics in a nonapoptotic programmed cell death. [PDF]

Cell Death Differ, 2020
Yalonetskaya A, Mondragon AA, Hintze ZJ, Holmes S, McCall K.   +4 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Applying machine learning to assist in the morphometric assessment of brain arteriolosclerosis through automation. [PDF]

Free Neuropathol
Lou JJ, Chang P, Nava KD, Chantaduly C, Wang HP, Yong WH, Patel V, Chaudhari AJ, Vasquez R, Monuki E, Head E, Vinters HV, Magaki S, Harvey DJ, Chuah CN, DeCarli CS, Williams CK, Keiser M, Dugger BN.   +18 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Distinct mammary stem cells orchestrate long-term homeostasis of adult mammary gland. [PDF]

Cell Discov
Lin Z, Guo Y, Bai H, Liu X, Lin M, Zhang Y, Tang R, Hu T, Yu L, Wang C, Cai S.   +10 more
europepmc   +1 more source