Results 61 to 70 of about 71,662 (334)
Nickel-catalyzed alkyl-arylation of 3,3,3-trifluoropropene
Communications Chemistry, 2022 3,3,3-Trifluoropropene is a cost-efficient precursor for the preparation of trifluoromethylated compounds, but limited methods for its efficient transformation have been reported.
Chang Xu +3 more
doaj +1 more source
Rapid iododeboronation with and without gold catalysis: application to radiolabelling of arenes [PDF]
, 2017 Radiopharmaceuticals incorporating radioactive iodine in combination with SPECT imaging play a key role in nuclear medicine, with applications in drug development and disease diagnosis.
Fletcher, Conor +5 more
core +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Expanding chemical space by para-C−H arylation of arenes
Nature Communications, 2022 Biaryls are privileged structural motif used in the discovery and design of therapeutics with high affinity and specificity for a broad range of protein targets.
Sudip Maiti +7 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Processes of adsorption/desorption of iodides and cadmium cations onto/from Ag(111) [PDF]
Journal of the Serbian Chemical Society, 2011 In this work, the adsorption/desorption processes of iodides and cadmium cations in the presence of iodides onto/from Ag(111) were investigated. It was shown that both processes were complex, characterized by several peaks on the cyclic voltammograms ...
VLADIMIR D. JOVIĆ, BORKA M. JOVIĆ
doaj
Application of Diaminium Iodides in Binary Ionic Liquid Electrolytes for Dye-Sensitized Solar Cells
International Journal of Photoenergy, 2011 N-(2-hydroxyethyl)ethylenediaminium iodides (HEEDAIs) and N-(2-hydroxyethyl)piperazinium iodides (HEPIs) were synthesized, and their thermal properties were analysed.
Yanzhen Yang +4 more
doaj +1 more source
Efficient Sonogashira Coupling Reaction Catalyzed by Copper (I) Iodide in the Presence of KF/Al2O3 [PDF]
شیمی کاربردی روز, 2009 We have developed a convenient and efficient method for coupling of aryl iodides and bromides with terminal alkynes. The protocol uses CuI as catalyst, 1, 10-phenanthroline as ligand, KF/Al2O3 as base and toluene as solvent.
Rahman Hosseinzadeh +2 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Nature Communications, 2023 Alkyl halides, widely recognized as important building blocks and reagents in organic synthesis, can serve as versatile alkyl radical precursors in radical-based transformations.
Xiang Sun, Ke Zheng
doaj +1 more source