Results 301 to 310 of about 3,027,527 (386)

Red‐Light‐Mediated Generation of Radicals: Applications in Organic Synthesis, Small‐Molecule Activation, Polymerization, and Bio‐Related Fields

open access: yesAngewandte Chemie International Edition, EarlyView.
Visible light‐driven photochemistry has advanced significantly, offering diverse methodologies in synthetic organic chemistry. Photocatalysis using red and near‐infrared (NIR) light is particularly notable due to its lower energy, reduced phototoxicity, minimized side reactions, and deeper penetration into reaction media.
Tong Zhang, Suman Pradhan, Shoubhik Das
wiley   +1 more source

The Chemistry and Biology of the Tetrodotoxin Natural Product Family

open access: yesAngewandte Chemie International Edition, Accepted Article.
Tetrodotoxin is a neurotoxic marine alkaloid, first isolated in 1909 from pufferfish and named after the biological order tetraodontiformes. Since its structural elucidation in 1964, it has attracted the interest of synthetic organic chemists due to its exceptional polarity, complex architecture, and important biological activity.
Benedikt Nißl   +6 more
wiley   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

open access: yesAngewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

Highly Enantioselective Organocatalysis with Bidentate Halogen Bond Donors

open access: yesAngewandte Chemie International Edition, EarlyView.
In a model Mukaiyama aldol reaction with unbiased substrates, high enantioselectivity was achieved with a modifiable bidentate iodine(I)‐based halogen bonding organocatalyst. The crucial role of halogen bonding was confirmed by the low performance of the corresponding hydrogen bond donor and via DFT calculations.
Julian Wolf   +6 more
wiley   +1 more source

Predicting A‐Element Substitution and MXene Formation in Reactions Between MAX Phases and Molten Salts

open access: yesAngewandte Chemie International Edition, Accepted Article.
Selective etching has emerged as a key method for synthesizing 2D materials, with the conversion of MAX phases to MXenes being by far the most widely studied and reported example. While traditional methods rely on etching in primarily acidic aqueous media, molten salts offer an intriguing alternative.
Jonas Björk, Johanna Rosen
wiley   +1 more source

Redox‐Switchable Poly‐Lewis Acids Allow the Controlled Release of Guests

open access: yesAngewandte Chemie International Edition, Accepted Article.
Presently, there is a notable interest in poly‐Lewis acids (PLAs), their host‐guest chemistry and their application in catalytic processes. The present study combines PLAs with redox‐active dibenzo[a,e]cyclooctatetraene (dbCOT) units. dbCOT‐based PLAs can be planarised by a two‐electron reduction.
Maximilian J. Klingsiek   +6 more
wiley   +1 more source

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