Results 231 to 240 of about 106,293 (333)

Nanodroplet Array Platform for Integrated Synthesis and Screening of MEK Inhibitors: a Miniaturized Approach to Early Drug Discovery

open access: yesAngewandte Chemie International Edition, EarlyView.
We present a nanodroplet array platform that integrates solid‐phase synthesis, MALDI‐MS analysis, and cell‐based screening. Using nanoliter droplets, we synthesized and tested 325 potential MEK inhibitors and identified 46 active compounds. This miniaturized approach combines chemistry and biology on a single chip, reducing time, cost, and material use
Maximilian Seifermann   +10 more
wiley   +1 more source

Bifunctional Probes Reveal the Rules of Intracellular Ether Lipid Transport

open access: yesAngewandte Chemie International Edition, EarlyView.
The article introduces the first bifunctional ether lipids that were used for comparative studies of ester and ether lipid transport in mammalian cells. We find differential recognition of alkyl ether and vinyl ether lipids (plasmalogens) by lipid transfer proteins indicating distinct functional roles within cells.
Kristin Böhlig   +6 more
wiley   +1 more source

Comparative Safety Profiles and Usage Patterns of Iodinated Contrast Media in Medical Imaging. [PDF]

open access: yesDiagnostics (Basel)
Shin YR   +6 more
europepmc   +1 more source

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