Synthesis of Oligonucleotide Conjugates Employing a Diselenide Linker
Chemistry – A European Journal, EarlyView.ABSTRACT In this study, we report the synthesis of an alkylene linker containing a terminal 2‐cyanoethyl protected selenium functionality for coupling at the 5'‐end of an oligonucleotide by solid phase synthesis for the preparation of oligonucleotide conjugates.
Shivam Tikoo +2 more
wiley +1 more source
Burden attributable to Iodine deficiency in Iran from 1990 to 2019: findings from Global Burden of Disease study. [PDF]
J Prev Med HygRasoulian P +8 more
europepmc +1 more source
Chemistry – A European Journal, EarlyView.Nitrooxylation—the installation of nitrate esters (–ONO2) has evolved from classical mixed‐acid protocols to catalytic and mechano‐, flow‐, photo‐, and electrochemical strategies. This review delineates ionic and radical manifolds for C–ONO2 bond formation, emphasizing mechanistic control, selected substrate scope, and selectivity.
Jayanta Dey, Dmitry Katayev
wiley +1 more source
Evaluating iodine deficiency and goiter in hilly areas of District Poonch Azad Jammu Kashmir. [PDF]
Pak J Med SciKhaliq A, Fayaz M, Hayat I, Abbas M.
europepmc +1 more source
Expanding Cyanide‐Bridged Weakly Coordinating Anions Through the Brominated Silver Salt Ag[BCNBBr]
Chemistry – A European Journal, EarlyView.The brominated weakly coordinating anion [μ‐(CN)(B(C6F4Br)3)2] ([BCNBBr]−), based on two B(C6F4Br)3 units bridged by cyanide, is obtained as its silver salt Ag[BCNBBr] from CH2Cl2. Ag[BCNBBr] enables oxidation and halide abstraction reactions, affording diverse [BCNBBr]− salts with oxidizing and electrophilic cations.
Amina L. Moshtaha +4 more
wiley +1 more source
Fluorogenic Sydnones for Bioorthogonal Labeling of DNA
Chemistry – A European Journal, EarlyView.Conjugates of sydnones with cyanine‐styryl dyes combine bioorthogonal reactivity with fluorogenicity. The reactivity with bicyclo[6.1.0]non‐4‐yne (BCN)‐modified DNA showed second‐order rate constants of up to k2 = 2,300 M−1s−1 and fluorescence turn‐on by one magnitude of order.
Kerstin Müller +1 more
wiley +1 more source
Does the island area also need to insist on salt iodization to prevent iodine deficiency disorders? a cross-sectional survey in Hainan Province, China. [PDF]
Front Endocrinol (Lausanne)Wu H +10 more
europepmc +1 more source
Stereochemical Control in the Matteson Reaction
Chemistry – A European Journal, EarlyView.The Matteson homologation is a highly versatile method for the stereoselective insertion of carbenoids into boronic esters. Through iterative application of the process, complex chiral molecules can be synthesized. The stereoselectivity of the reaction is determined by a chiral diol incorporated in the boronic ester.
Hae Mo Lee, Christoph Hirschhäuser
wiley +1 more source
Trends in three malnutrition factors in the global burden of disease: iodine deficiency, vitamin A deficiency, and protein-energy malnutrition (1990-2019). [PDF]
Front NutrJi S, Zhou Y, Zhao Q, Chen R, Su Z.
europepmc +1 more source
Interplay of Bridge Topology and Conformation in Phenylene‐Bridged Trityl Diradicals
Chemistry – A European Journal, EarlyView.We present a meta‐phenylene‐bridged trityl diradical that exhibits an unexpectedly weak antiferromagnetic exchange coupling J with a strong environment‐dependent magnitude. Combined VSM, EPR, DFT, and MD studies reveal that structural flexibility modulates σ‐, π‐, and through‐space exchange contributions, highlighting the crucial role of geometry in ...
Kevin Lars Kopp +4 more
wiley +1 more source