Results 151 to 160 of about 646,282 (280)

C‐Terminal Functionalization Methods of Amino Acids, Peptides, and Proteins

open access: yesChemistry – A European Journal, EarlyView.
C‐terminal functionalization offers powerful routes to peptide and protein diversification, yet epimerization, hydrolysis, and selectivity remain key challenges. This Review surveys enzymatic, decarboxylative, and condensation strategies, highlighting advances toward chemo‐ and regioselective, protecting‐group‐free, atom‐efficient methods applicable to
Jay Hanssens   +3 more
wiley   +1 more source

Trends and Future Directions in Organic Chemistry for Drug Discovery

open access: yesChemistry – A European Journal, EarlyView.
Organic synthesis is being reshaped by the convergence of catalytic innovation, automation, artificial intelligence, and emerging therapeutic modalities. Late‐stage functionalization, photoredox and electrochemical methods, biocatalysis, flow chemistry, DELs, and proximity‐based drugs are examined as components of closed‐loop discovery.
Paweł Kozyra, Maciej Masłyk
wiley   +1 more source

Cyclic Disulfide Sorting Influenced by Subtle Steric and Electronic Effects

open access: yesChemistry – A European Journal, EarlyView.
The self‐assembly of two unsymmetrical dithiols to form cyclic disulfides are examined with an eye to the longitudinal equilibration behavior and directing agent effects on product distributions. Cyclic disulfide formation occurs in under 2 min, with full equilibration requiring up to 1 week.
Willow A. Davis   +7 more
wiley   +1 more source

Reversible Humidity‐Induced Vapochromism of a Cu(II) Tetramine Complex Driven by Iodide Access

open access: yesChemistry – A European Journal, EarlyView.
A humidity‐responsive Cu(II) vapochromic complex based on reversible iodide coordination is reported. Unlike the chloride and bromide analogues, [Cu(chxn)2(H2O)2]I2 exhibits rapid and reversible color changes with humidity. Spectroscopic, diffraction, ESR, and DFT studies reveal that dehydration induces axial iodide coordination to form [Cu(chxn)2I2 ...
Masanori Wakizaka   +4 more
wiley   +1 more source

Total Synthesis and Absolute Configuration of the Irregular Tetraterpene Viaticene A

open access: yesChemistry – A European Journal, EarlyView.
Viaticenes are tetraterpenes with a unique [6+2]‐connectivity from the springtail Hypogastrura viatica. Here, we report a modular 13‐step total synthesis of viaticene A, featuring stereoselective double‐bond formation, a Cu‐mediated allylic substitution, and Ni/Co‐cocatalyzed vinyl‐alkyl cross‐electrophile coupling as key steps.
Patrick Stamm   +3 more
wiley   +1 more source

A lumped modelling framework for the epoxidation of vegetable oils and fatty acid methyl esters

open access: yesThe Canadian Journal of Chemical Engineering, EarlyView.
Abstract Epoxidized vegetable oils and fatty acid methyl esters are promising bio‐based alternatives to phthalates for plasticizer applications. Their synthesis typically involves the reaction of unsaturated double bonds with peracetic acid in a biphasic liquid–liquid system, where the simultaneous occurrence of reaction and phase partitioning makes ...
Irene Presti   +3 more
wiley   +1 more source

Learning Strategies from Nature's Blueprint to Cyclic Carbonate Synthesis

open access: yesChemSusChem, Volume 18, Issue 6, March 15, 2025.
The development of sustainable synthetic methods for cyclic carbonates draws inspiration from nature, focusing on eco‐friendly processes and renewable resources like CO2 and biomass. This review explore various CO2 activation mechanisms, green chemistry principles, and green catalysts.
Erika Saccullo   +4 more
wiley   +1 more source

Recent Advance for PVDF Based Flexible Piezoelectric Sensors

open access: yesEcoEnergy, EarlyView.
This review focus on the structural regulation of PVDF via boundary confinement, blending regulation, electric‐field‐assisted orientation, and chemical modification for flexible piezoelectric sensors. ABSTRACT The rapid advancement of flexible electronics, wearable devices, and biomedical engineering has spurred increasing demand for sensor materials ...
Chaoran Tan   +4 more
wiley   +1 more source

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