Results 91 to 97 of about 99 (97)

Development of Water‐Soluble 3‐Nitro‐2‐Pyridinesulfenate for Disulfide Bond Formation of Peptide Under Aqueous Conditions

Chemistry – A European Journal, EarlyView.
Highly water‐soluble Npy‐sulfenate functions as an efficient oxidizing agent for the formation of disulfide bonds in thiol‐containing peptides. The Npy‐sulfenate can be used to form a disulfide bond with a thiol‐containing peptide produced by thiol‐additive‐free NCL, thereby facilitating the one‐pot synthesis of adrenomedullin.
Akihiro Taguchi, Megumi Sakata, Ryusei Yamamoto, Hayate Shida, Saeka Kuraishi, Sho Konno, Kentaro Takayama, Atsuhiko Taniguchi, Yoshio Hayashi   +8 more
wiley   +1 more source

Late‐Stage Intermolecular O‐Peptidylation Protocol Enabled by Sequential Acyl Transfer on Thiol‐Incorporated Threonine Followed by Desulfurization

Chemistry – A European Journal, EarlyView.
The late‐stage intermolecular O‐acylation of the threonine (Thr) side chain was accomplished by reacting thiol‐incorporated Thr with a peptide thioester in open air. The thioester, which contained the volatile trifluoroethanethiol, facilitated the formation of S,O‐diacyl peptides.
Daiki Sato, Rika Ota, Chiho Shinozaki, Masaya Denda, Akira Otaka   +4 more
wiley   +1 more source

Affinity‐Based Protein Profiling Reveals IDH2 as a Mitochondrial Target of Cannabinol in Receptor‐Independent Neuroprotection

Chemistry – A European Journal, EarlyView.
A chemical probe CBN‐P based on the neuroprotective cannabinoid cannabinol (CBN) was developed and synthesized. CNB‐P was found to have a similar mechanism of action as the parent compound and was used in click‐CLEM microscopy studies and affinity‐based protein profiling to identify the mitochondrial protein isocitrate dehydrogenase 2 (IDH2) as one ...
Eva Schaller, Stephanie Lamer, Andreas Schlosser, Christian Stigloher, Pamela Maher, Michael Decker   +5 more
wiley   +1 more source

Late‐Stage Amination of Peptides on the Solid Phase

Chemistry – A European Journal, EarlyView.
The introduction of amines into peptides via an on‐resin iodination‐substitution reaction sequence provides access to a wide variety of modifications, including amine‐based metal ligands. Primary, secondary, and aromatic amines, as well as heteroaromatic N‐nucleophiles, have been successfully incorporated into the reaction sequence.
Julian Brinkhofer, Marius Werner, Agon Kokollari, Shih‐Yu Pan, Christian Klein, Truc Lam Pham, Franziska Thomas   +6 more
wiley   +1 more source

Recent Advances in Detergent Chemistry and Handling Support Membrane Protein Analysis Including Lipid Interactions

Chemistry – A European Journal, EarlyView.
Detergent design parameters determine experimental successes in membrane protein research. Recent progresses in detergent chemistry are reviewed to promote the top‐down design of non‐ionic detergents for the purification and analysis of intact membrane proteins, including lipid interactions.
Katharina Alker, Jan‐Simon Behnke, Leonhard H. Urner   +2 more
wiley   +1 more source

Carbohydrate Wastes to Chemicals (CtC): From Second‐Generation Sugars to Glycols

Chemie Ingenieur Technik, EarlyView.
The Carbohydrate Wastes to Chemicals (CtC) project examined an alternative and sustainable route to the production of glycols with propylene glycol as the main product. Thereby, the utilization of carbohydrate‐containing residues as second‐generation sugars was researched as alternative biogenic feedstock from biomass.
Giuseppe Cusati, Hannah Fergen, Marine Bouge, Thomas Bücker, Kevin Vogel, Mehran Taherkhani, Ralf Ehret   +6 more
wiley   +1 more source

Ecologic and Economic Evaluation of Combined Methanol Synthesis from CO2 and Biotechnological Upgrading to Value Products. Part 1: Environmental Impact

Chemie Ingenieur Technik, EarlyView.
The combination of methanol synthesis and biotechnological upgrading to value‐added products still faces some challenges in order to achieve a positive environmental impact and thus the goal of synergetic development of biotechnological and chemical processes.
Mehran Taherkhani, Niels Hanau, Rebecca Lehmpfuhl, Ralf Ehret   +3 more
wiley   +1 more source