Results 81 to 90 of about 2,104,284 (365)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
The diver's life is in their hands [picture]
, 1937 Part of collection: Ion Idriess glass plate negative collection.; Title from caption in: Forty fathoms deep.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn3298470; Published in: Forty fathoms deep : pearl ...
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Journal of Physical Chemistry B, 2008 Alkali (Li+, Na+, K+, Rb+, and Cs+) and halide (F−, Cl−, Br−, and I−) ions play an important role in many biological phenomena, roles that range from stabilization of biomolecular structure, to influence on biomolecular dynamics, to key physiological ...
InSuk Joung, T. Cheatham
semanticscholar +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
, 1935 Part of collection: Ion Idriess glass plate negative collection.; Title from caption in: Man tracks.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn3298444; Published in: Man tracks : with the mounted police in ...
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INFLUENCE OF PLASMA NITRIDING ON SURFACE ROUGHNESS OF STEELS
Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019 The research results of the influence of plasma at different levels of surface roughness are presented. The objective of this work is to determine the effects of plasma after the treatment for instrument steel 40Cr and construction steel 38H2MYUA.
M. S. Ahmed, A. N. Drobov
doaj
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A hunting party on an island off the Kimberley coast [Western Australia] [picture]
, 1963 Condition: Good.; Part of collection: Ion Idriess glass plate negative collection.; Title from caption in: Our living stone age.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn3299226; Published in: Our living ...
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, 2011 The effects of kinetic energy on the outcomes of exothermic and endothermic ion/molecule reactions in a quadrupole ion trap mass spectrometer are examined.
Wu, H. F. ; 吳慧芬; Brodbelt, J. S.
core +1 more source