Results 131 to 140 of about 1,025,431 (370)
Asymmetry of movements in CFTR's two ATP sites during pore opening serves their distinct functions
eLife, 2017 CFTR, the chloride channel mutated in cystic fibrosis (CF) patients, is opened by ATP binding to two cytosolic nucleotide binding domains (NBDs), but pore-domain mutations may also impair gating.
Ben Sorum +2 more
doaj +1 more source
Evolutionary Analysis of Biological Excitability [PDF]
arXiv, 2006 Excitability is an attribute of life, and is a driving force in the descent of complexity. Cellular electrical activity as realized by membrane proteins that act as either channels or transporters is the basis of excitability. Electrical signaling is mediated by a wave of action potentials, which consist of synchronous redistribution of ionic gradients
arxiv
Journal of Applied Clinical Medical Physics, EarlyView.Abstract The establishment of guidelines and curriculum standards for medical physics residency training is a critical component of setting expectations and competencies for the profession. Since the last publication of these standards, residency training has become integrated into the eligibility criteria for most medical physics certification bodies.
Jonathon A. Nye +16 more
wiley +1 more source
In-Silico Investigation of Phyllanthus niruri Phytochemicals as Hepatic Fibrosis Modulators
Biology and Life Sciences ForumThe liver is a pioneer internal organ that orchestrates major metabolic, detoxification, and endocrine roles. Acute factors like hepatitis and drug allergy and chronic causes like metabolic dysfunction-associated fatty liver disease (MASLD) and ...
Chithra Raju, Kavitha Sankaranarayanan
doaj +1 more source
The sodium-leak channel, NALCN, in health and disease
Frontiers in Cellular Neuroscience, 2014 Ion channels are crucial components of cellular excitability and are involved in many neurological diseases. This review focuses on the sodium leak, G protein-coupled receptors (GPCRs)-activated NALCN channel that is predominantly expressed in neurons ...
Maud eCochet-Bissuel +11 more
doaj +1 more source
A Review of Mathematical Modeling, Simulation and Analysis of Membrane Channel Charge Transport [PDF]
arXiv, 2016 The molecular mechanism of ion channel gating and substrate modulation is elusive for many voltage gated ion channels, such as eukaryotic sodium ones. The understanding of channel functions is a pressing issue in molecular biophysics and biology.
arxiv
Developing reference plans for evaluating global clinical trials credentialing and PSQA systems
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose To develop a practical framework for creating a diverse set of validated reference plans (varying in complexity) and implement a workflow to introduce beam modeling, calibration, and delivery errors into the reference cohort to test and compare various dosimetry audit methodologies.
Fre'Etta M. D. Brooks +13 more
wiley +1 more source
Two-Channel Model for Electron Transfer in Ion–Molecule Collisions [PDF]
, 1969 Gerald R. North, J. J. Leventhal
openalex +1 more source
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose The aim of this work was to report on the optimization, commissioning, and validation of a beam model using a commercial independent dose verification software RadCalc version 7.2 (Lifeline Software Inc, Tyler, TX, USA), along with 4 years of experience employing RadCalc for offline and online monitor unit (MU) verification on the ...
Urszula Jelen +3 more
wiley +1 more source
TRPV4 is the temperature-sensitive ion channel of human sperm. [PDF]
, 2018 Ion channels control the ability of human sperm to fertilize the egg by triggering hyperactivated motility, which is regulated by membrane potential, intracellular pH, and cytosolic calcium.
Lishko, Polina V +2 more
core +2 more sources