Results 71 to 80 of about 948,699 (249)
TRP Channels Regulation of Rho GTPases in Brain Context and Diseases
Frontiers in Cell and Developmental Biology, 2020 Neurological and neuropsychiatric disorders are mediated by several pathophysiological mechanisms, including developmental and degenerative abnormalities caused primarily by disturbances in cell migration, structural plasticity of the synapse, and blood ...
Boris Lavanderos +12 more
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Cystic fibrosis drug ivacaftor stimulates CFTR channels at picomolar concentrations
eLife, 2019 The devastating inherited disease cystic fibrosis (CF) is caused by mutations of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) anion channel.
László Csanády, Beáta Töröcsik
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ION CHANNELS OF NOCICEPTION [PDF]
Annual Review of Physiology, 1999 ▪ Abstract Nociceptors are the first cells in the series of neurons that lead to the sensation of pain. The essential functions of nociceptors—transducing noxious stimuli into depolarizations that trigger action potentials, conducting the action potentials from the peripheral sensory site to the synapse in the central nervous system, and converting ...
Michael S. Gold, Edwin W. McCleskey
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Monitoring Ion Channel Function In Real Time Through Quantum Decoherence
, 2009 In drug discovery research there is a clear and urgent need for non-invasive detection of cell membrane ion channel operation with wide-field capability.
Arhem +30 more
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Enhancement of laser-driven electron acceleration in an ion channel [PDF]
, 2013 A long laser beam propagating through an underdense plasma produces a positively charged ion channel by expelling plasma electrons in the transverse direction.
Arefiev, Alexey V. +2 more
core +1 more source
Silica nanoparticles inhibit the cation channel TRPV4 in airway epithelial cells
Particle and Fibre Toxicology, 2017 Background Silica nanoparticles (SiNPs) have numerous beneficial properties and are extensively used in cosmetics and food industries as anti-caking, densifying and hydrophobic agents.
Alicia Sanchez +9 more
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Membranes, 2022 This study was focused on the action of lantibiotic nisin on the phospholipid membranes. Nisin did not produce ion-permeable pores in the membranes composed of DOPC or DOPE. The introduction of DOPS into bilayer lipid composition led to a decrease in the
Dayana N. Chernyshova +3 more
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Ion channel expression in human melanoma samples. in silico identification and experimental validation of molecular targets [PDF]
, 2019 Expression of 328 ion channel genes was investigated, by in silico analysis, in 170 human melanoma samples and controls. Ninety-one members of this gene-family (i.e., about 28%) show a significant (p 0.90 and p 90% in most cases).
D’Arcangelo, Daniela +5 more
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Scientific ReportsThe toxin AaH-II, from the scorpion Androctonus australis Hector venom, is a 64 amino acid peptide that targets voltage-gated Na+ channels (VGNCs) and slows their inactivation. While at macroscopic cellular level AaH-II prolongs the action potential (AP),
Fatima Abbas +5 more
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Ion channel activity drives ion channel expression [PDF]
The Journal of Physiology, 1998 During embryonic development, excitable cells acquire a repertoire of ion channels that finely tune their electrical properties. Although the mechanisms by which an excitable cell selects its complement of ion channels are poorly defined, cell-autonomous as well as non-autonomous programmes of differentiation have been implicated.
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