Results 71 to 80 of about 325,795 (314)

High throughput clone screening on overexpressed hERG1 and Kv1.3 potassium channels using ion channel reader (ICR) label free technology [PDF]

, 2023
Alberto Montalbano, Cesare Sala, Ginevra Chioccioli Altadonna, Andrea Becchetti, Annarosa Arcangeli   +4 more
openalex   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Gating modulation and potentiation of amiodarone blockage of the Kv10.1 potassium channel bu KB130015, an amiodarone derived molecule

Channels
Kv10.1 is a voltage-gated K+ channel whose structure–function relationships remain incompletely understood, and whose ectopic expression is linked to tumorigenesis.
Froylán Gómez-Lagunas, Carolina Barriga-Montoya   +1 more
doaj   +1 more source

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Membrane-Mediated Action of Phosphodiesterase 5 Inhibitors

Pharmaceutics
Background/Objectives: Phosphodiesterase 5 (PDE5) inhibitors, sildenafil, vardenafil, and tadalafil, activate the cyclic guanosine monophosphate pathway resulting in vascular smooth muscle relaxation.
Anna I. Malykhina, Svetlana S. Efimova, Olga S. Ostroumova   +2 more
doaj   +1 more source

TRPV4 Mediates Acute Bladder Responses to Bacterial Lipopolysaccharides

Frontiers in Immunology, 2020
Urinary tract infections (UTI) affect a large proportion of the population, causing among other symptoms, more frequent and urgent micturition. Previous studies reported that the gram-negative bacterial wall component lipopolysaccharides (LPS) trigger ...
Yeranddy A. Alpizar, Yeranddy A. Alpizar, Pieter Uvin, Pieter Uvin, Robbe Naert, Robbe Naert, Jan Franken, Jan Franken, Silvia Pinto, Silvia Pinto, Alicia Sanchez, Alicia Sanchez, Thomas Gevaert, Wouter Everaerts, Wouter Everaerts, Thomas Voets, Thomas Voets, Dirk De Ridder, Karel Talavera, Karel Talavera   +19 more
doaj   +1 more source

Chronic Administration of Ion Channel Blockers Impact Microglia Morphology and Function in a Murine Model of Alzheimer’s Disease [PDF]

, 2023
Ianis Kevyn Ştefan Boboc, Alexandru Cojocaru, Gabriel Nedelea, Bogdan Cătălin, Mária Bogdán, Daniela Călina   +5 more
openalex   +1 more source

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

Electrophysiological classification of CACNA1G gene variants associated with neurodevelopmental and neurological disorders

Frontiers in Pharmacology
This study highlights the complementarity of automated patch-clamp (APC) and manual patch-clamp (MPC) approaches to describe the electrophysiological properties of eighteen Cav3.1 calcium channel variants associated with various neurological conditions ...
Amaël Davakan, Amaël Davakan, Leos Cmarko, Leos Cmarko, Leos Cmarko, Leos Cmarko, Barbara Ribeiro Oliveira-Mendes, Barbara Ribeiro Oliveira-Mendes, Claire Bernat, Claire Bernat, Najlae Boulali, Najlae Boulali, Jérôme Montnach, Jérôme Montnach, Stephanie E. Vallee, Mary B. Dinulos, Lydie Burglen, Lydie Burglen, Vincent Cantagrel, Norbert Weiss, Sophie Nicole, Sophie Nicole, Arnaud Monteil, Arnaud Monteil, Michel De Waard, Michel De Waard, Philippe Lory, Philippe Lory   +27 more
doaj   +1 more source

Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol

eLife, 2019
The cation channel TRPA1 transduces a myriad of noxious chemical stimuli into nociceptor electrical excitation and neuropeptide release, leading to pain and neurogenic inflammation.
Justyna B Startek, Brett Boonen, Alejandro López-Requena, Ariel Talavera, Yeranddy A Alpizar, Debapriya Ghosh, Nele Van Ranst, Bernd Nilius, Thomas Voets, Karel Talavera   +9 more
doaj   +1 more source