Results 131 to 140 of about 114,766 (235)

Impact of linker-drug on ion exchange chromatography separation of antibody-drug conjugates. [PDF]

MAbs, 2019
Zhang Z, Zhou S, Han L, Zhang Q, Pritts WA.   +4 more
europepmc   +1 more source

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

Publisher Correction: Coupling Multi Angle Light Scattering to Ion Exchange chromatography (IEX-MALS) for protein characterization. [PDF]

Sci Rep, 2019
Amartely H, Avraham O, Friedler A, Livnah O, Lebendiker M.   +4 more
europepmc   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Targeted CQA analytical control strategy for commercial antibody products: Replacing ion-exchange chromatography methods for charge heterogeneity with multi-attribute monitoring. [PDF]

MAbs
Evans AR, Mulholland J, Lewis MJ, Hu P.
europepmc   +1 more source

Online Size-exclusion and Ion-exchange Chromatography on a SAXS Beamline. [PDF]

J Vis Exp, 2017
Brennich ME, Round AR, Hutin S.
europepmc   +1 more source

High Free‐Volume Imidazole‐Based Ionomers for High‐Temperature Proton Exchange Membrane Fuel Cells

Advanced Science, EarlyView.
High free‐volume imidazole‐based ionomers (PF4IM‐72) enable enhanced phosphoric acid uptake and efficient proton transport, delivering peak power densities of 0.645 W cm−2 at 160 °C and 0.838 W cm−2 at 200 °C in HT‐PEMFCs. This work highlights a promising platform for next‐generation ionomers with improved high‐temperature performance and stability ...
Ge Chao, Hyeon Keun Cho, Chang Yeon Hyun, Shirong Li, Jong Geun Seong, So Young Lee, Nanwen Li, Young Moo Lee   +7 more
wiley   +1 more source

Coupling Multi Angle Light Scattering to Ion Exchange chromatography (IEX-MALS) for protein characterization. [PDF]

Sci Rep, 2018
Amartely H, Avraham O, Friedler A, Livnah O, Lebendiker M.   +4 more
europepmc   +1 more source

Intramolecular Interactions between Folded and Disordered Regions Shape Ubiquilin Structure and Function

Advanced Science, EarlyView.
Ubiquilin (UBQLN), like many other human proteins, contains both well‐folded and disordered regions. Here, we show that intramolecular interactions between disordered regions and folded domains modulate between open and closed topologies of UBQLN proteins, altering their structure and function.
Jessica K. Niblo, Nirbhik Acharya, Maxwell B. Watkins, Carlos A. Castañeda, Shahar Sukenik   +4 more
wiley   +1 more source

[Determination of trace anions in G2-grade phosphoric acid using two-dimensional ion-exclusion-ion-exchange chromatography with valve-switching technology]. [PDF]

Se Pu
Wang JD, Tang G, Lu Y, Lu HJ, Ye T.
europepmc   +1 more source