Results 101 to 110 of about 24,155 (261)

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity. [PDF]

, 2019
Deletion of phenylalanine 508 (F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel is the most frequent mutation causing cystic fibrosis (CF). F508del-CFTR is misfolded and prematurely degraded. Recently thymosin a-1 (
Armirotti, Andrea, Braccia, Clarissa, Cholon, Deborah M, Galietta, Luis JV, Gentzsch, Martina, Guidone, Daniela, Hanrahan, John W, Lukacs, Gergely L, Matthes, Elizabeth, Pedemonte, Nicoletta, Phuan, Puay-Wah, Tomati, Valeria, Veit, Guido, Verkman, Alan S   +13 more
core  

A chromatographic approach to distinguish Gram-positive from Gram-negative bacteria using exogenous volatile organic compound metabolites [PDF]

, 2017
This paper utilized L-alanine aminopeptidase activity as a useful approach to distinguish between Gram-negative and Gram-positive bacteria. This was done using two enzyme substrates, specifically 2-amino-N-phenylpropanamide and 2-amino-N-(4-methylphenyl ...
Dean, John, Perez-Perez, Ma. Cristina, Perry, John, Ramírez-Guízar, Susana, Schwalbe, Ed, Stanforth, Stephen, Sykes, Hannah   +6 more
core   +2 more sources

Clinical Applications of Phosphoproteomics: Illuminating Cancer Signaling and Enabling Rational Therapeutic Strategies

Cancer Science, EarlyView.
Mass spectrometry‐based phosphoproteomics for mechanistic dissection of cancer signaling pathways and uncovering therapeutic vulnerabilities. ABSTRACT Protein phosphorylation is a central post‐translational modification regulating cellular signaling, frequently dysregulated in cancer.
Hirokazu Shoji, Narikazu Boku, Jun Adachi   +2 more
wiley   +1 more source

Research on the application of liquid-liquid extraction-gas chromatography-mass spectrometry (LLE-GC-MS) and headspace-gas chromatography-ion mobility spectrometry (HS-GC-IMS) in distinguishing the Baiyunbian aged liquors

, 2020
The purpose of the study was to reveal the differences of the flavor compounds among five Baiyunbian aged liquors by liquid-liquid extraction-gas chromatography-mass spectrometry (LLE-GC-MS) and headspace-gas chromatography-ion mobility spectrometry (HS ...
Rong-Qi Zhou, Xiao Chen, Ying Xia, M. Chen, Yu Zhang, Qin Li, D. Zhen, S. Fang   +7 more
semanticscholar   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Development of Tandem Ion Mobility Spectrometry with High-voltage Fragmentation Unit at Atmospheric Pressure for Explosives Detection

Zhipu Xuebao
Trace explosive detection is an essential aspect for ensuring public safety. Ion mobility spectrometry (IMS) is an effective technique for detecting explosives and compounds related to explosives.
Kang-yi LIU, Tian-xin XIAN, Ling-feng LI, Yun-jing ZHANG, Xing-li HE, Peng LI   +5 more
doaj   +1 more source

Characterisation of a cold‐adapted, thermostable glucokinase from psychrophilic Pseudoalteromonas sp. AS‐131 reveals how the enzyme achieves high thermal stability without loss of cold adaptation

The FEBS Journal, EarlyView.
We investigated glucokinase from the psychrophilic Pseudoalteromonas sp. AS‐131 (PsGK), which was isolated from the Antarctic Ocean. Biochemical studies revealed that PsGK is a cold‐adapted enzyme with high thermal stability, in contrast to general cold‐adapted enzymes, which have low thermal stability.
Akane Yato, Yuki Kato, Fuyuko Hayashi, Rio Asaka, Atsuko Ogawa, Tokuro Oda, Sayaka Tsuji, Masashi Unno, Nobuaki Soh, Keiichi Watanabe, Masaki Horitani   +10 more
wiley   +1 more source

Development of atmospheric pressure ionization ion mobility spectrometry and ion mobility spectrometry mass spectrometry [PDF]

, 2012
This study is focused on the development and evaluation of ion mobility instrumentation with various atmospheric pressure ionization techniques and includes the following work.
Adamov, Alexey
core  

A modular computational framework for automated peak extraction from ion mobility spectra [PDF]

, 2007
 There was considered the possibility of the air field lights simulation in the imitators of flight simulator. The attempt of forming the database of the air field lights with realization in the lighting program DIALux is presented in this paper ...
Marianna D’Addario, Dominik Kopczynski, Jörg Baumbach, Sven Rahmann   +3 more
core   +3 more sources

FluoroMatch IM: An Interactive Software for PFAS Analysis by Ion Mobility Spectrometry

Environmental Science & Technology
Per- and polyfluoroalkyl substances (PFASs) are often present in complex mixtures at trace levels in environmental samples, posing difficulties for analytical chemists. Ion mobility offers highly replicable identifiers, enabling the use of community-based libraries for PFAS annotation in nontargeted analysis.
Rachel Smolinski, Jeremy P. Koelmel, Paul Stelben, David Weil, David Godri, David Schiessel, Michael Kummer, Sarah M. Stow, Sheher Mohsin, Lauren Royer, Alan McKenzie-Coe, Thomas Lubinsky, Daniel DeBord, Olivier Chevallier, Emma E. Rennie, Krystal J. Godri Pollitt, Carrie McDonough   +16 more
openaire   +2 more sources