Results 61 to 70 of about 3,765,863 (364)

Benzothiazole durch C-C-Spaltung von alpha-[(2-Nitrophenyl)thio]ketonen [PDF]

, 1984
Einwirkung von Ammoniak bzw. Natronlauge auf die -[(2-Nitrophenyl)thio]ketone 4, 11a-c und 16 führt unter CC-Spaltung zu den Benzothiazol-N-oxid-Derivaten 8, 12ac und 17; aus dem 3-[(2-Nitrophenyl)thio]-4-piperidon-Derivat 22 entsteht der 2 ...
Babichev, Birkofer, Eiden, Gordon, Hoffmann, Hofmann, House, Kuehne, Linke, Schröder, Takahashi   +10 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Cambios temporales y espaciales en la química del agua superficial en un río mediterráneo de Chile central: el caso del río Mataquito (~35°S)

Tecnología y ciencias del agua, 2023
Se evaluaron los cambios espaciales y temporales en la química del agua superficial de un río Mediterráneo, i.e., río Mataquito, Chile central. Los procesos que controlan la dinámica de la química del agua en la cuenca se determinaron evaluando la ...
Juan A. Placencia, Patricio Torres-Ramírez, José Ortiz-Riquero, Rodolfo Jerez-Ruiz   +3 more
doaj   +1 more source

Nidificación del Chinchero Escamado (Lepidocolaptes falcinellus) [PDF]

, 2011
We provide the first description of the nest of the Scalloped Woodcreeper (Lepidocolaptes falcinellus), its clutch size, nestlings, and nesting behavior from prospecting to fledging, based on 102 h of observation at a nest in the subtropical Atlantic ...
Bodrati, Alejandro, Cockle, Kristina Louise   +1 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Durabilidad del hormigón. Influencia de la concentración de cloruros en el agua de amasado y en disolución [PDF]

, 1995
The most aggressive situation which is responsible for most of the cases of steel reinforcement corrosion in concrete, takes place when chlorides are present in the environment.
Barrios Sevilla, Jesús, Flores Luque, Vicente, López Villarino, Begoña, Rodríguez García, María Reyes   +3 more
core   +2 more sources

Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group

Journal of Immunotherapy for Cancer, 2017
Cancer immunotherapy has transformed the treatment of cancer. However, increasing use of immune-based therapies, including the widely used class of agents known as immune checkpoint inhibitors, has exposed a discrete group of immune-related adverse ...
I. Puzanov, A. Diab, K. Abdallah, C. Bingham, C. Brogdon, R. Dadu, L. Hamad, S. Kim, M. Lacouture, N. LeBoeuf, D. Lenihan, C. Onofrei, V. Shannon, R. Sharma, A. Silk, D. Skondra, M. Suarez‐Almazor, Y. Wang, K. Wiley, H. Kaufman, M. Ernstoff, Jeff Deborah Stephanie Joan Janie Daniel David Ion Rena Anderson Arrindell Andrews Ballesteros Boyer Chen , J. Anderson, Deborah Arrindell, S. Andrews, J. Ballesteros, J. Boyer, Daniel S Chen, David Chonzi, I. Cotarla, R. Cunha, M. Davies, M. Dawson, A. Dicker, L. Eifler, Andrew D. Ferguson, C. Ferlini, S. Frankel, W. Go, Celestine G. Gochett, J. Goldberg, P. Goncalves, T. Goswami, Nancy C. Gregory, J. Gulley, V. Hayreh, Nicole Helie, William C. Holmes, Jer-Yuan hsu, R. Ibrahim, C. Larocca, K. Lehman, S. Ley-Acosta, O. Lambotte, J. Luke, J. Mcclure, Elisabete Michelon, Mary C. Nakamura, K. Patel, B. Piperdi, Z. Rasheed, D. Reshef, J. Riemer, C. Robert, M. Sarkeshik, Ann Saylors, J. Schreiber, K. Shafer-Weaver, W. Sharfman, E. Sharon, R. Sherry, C. Simonson, C. Thomas, John A Thompson, E. Trehu, D. Tresnan, M. Turner, Darshan Wariabharaj, I. Waxman, L. Wood, Lin Zhang, P. Zheng   +81 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Negociaciones: Que Es La Verdad? Circa 1979 [PDF]

, 1979
In Spanish.

core   +1 more source