Results 61 to 70 of about 72,909 (315)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Ionic Liquids and Catalysis

Journal of the Brazilian Chemical Society, 2014
This paper explores the growing number of publications concerning the use of ionic liquids (ILs) in the period from 1994 to 2013. Catalysis can be identified as the area responsible for the surge of interest in ILs. The same is true for the Brazilian scientific community.
openaire   +4 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

CO₂/CH₄ Separation in Amino Acid Ionic Liquids, Polymerized Ionic Liquids, and Mixed Matrix Membranes

Molecules
The ability to efficiently separate CO2 from other light gases using membrane technology has received a great deal of attention due to its importance in applications such as improving the efficiency of natural gas and reducing greenhouse gas emissions. A
Gowri Selvaraj, Cecilia Devi Wilfred
doaj   +1 more source

Optimization of the Synthesis of Superhydrophobic Carbon Nanomaterials by Chemical Vapor Deposition

Scientific Reports, 2018
Demand is increasing for superhydrophobic materials in many applications, such as membrane distillation, separation and special coating technologies. In this study, we report a chemical vapor deposition (CVD) process to fabricate superhydrophobic carbon ...
Mustafa Mohammed Aljumaily, Mohammed Abdulhakim Alsaadi, Rasel Das, Sharifah Bee Abd Hamid, N. Awanis Hashim, Mohamed Khalid AlOmar, Haiyam Mohammed Alayan, Mikhail Novikov, Qusay F. Alsalhy, Mohd Ali Hashim   +9 more
doaj   +1 more source

Mixtures of ionic liquids

Chemical Society Reviews, 2012
Simple ionic liquids have long been held to be designer solvents, based upon the ability to independently vary their cations and anions. The formation of mixtures of ionic liquids increases this synthetic flexibility. We review the available literature of these ionic liquid mixtures to identify how their properties change and the possibility for their ...
Niedermeyer, H, Hallett, JP, Villar-Garcia, IJ, Hunt, PA, Welton, T   +4 more
openaire   +4 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Ionic Liquids as (Co-)Solvents for Nonhydrolytic Enzymes

, 2012
Summary This chapter contains sections titled: Nomenclature of ILs Ionic Liquids and Nonhydrolytic Enzymes Use of ILs in Oxidoreductase-Catalyzed Enzymatic Reactions ILs in Lyase-Catalyzed Reactions Prospects ...
Daniela Gamenara, Gustavo Seoane, Pablo Domínguez de María, Seoane, Gustavo,, Gamenara, Daniela,, Saenz Mendez, Patricia,, Dominguez de Maria, Pablo,, Patricia Saenz Méndez   +7 more
core   +1 more source

Ionic Liquids as Antifungal Agents for Wood Preservation

, 2020
Ionic liquids represent a class of highly versatile organic compounds used extensively in the last decade for lignocellulose biomass fractionation and dissolution, as well as property modifiers for wood materials.
Ionut Claudiu Roata, Catalin Croitoru
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source