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Protection Against Nephrotoxicity of Iothalamic Acid [PDF]
Archives of Surgery, 1964 Previous studies in this laboratory have quantitated and compared the nephrotoxicity of the various aortographic contrast media.4,8,14An 80% solution of iothalamic acid (Angio-Conray) has proven to be one of the least nephrotoxic of the currently available aortographic contrast media.1,12,14However, use of a standardized canine aortic injection ...
John H. Foster +2 more
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Acta Radiologica. Diagnosis, 1977
The effects of electrolytes, osmolality, pH, PaO2, PaCO2, hematocrit, blood volume and coagulation occurring after a rapid intra-aortic injection of a monomer and a dimer (salts of methylglucamine of the iothalamic and iocarmic acids) were compared. The effects of the monomer agreed with previous results but the effects of the dimer differed from those
Duc R, Barbe R, Amiel M
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The effects of electrolytes, osmolality, pH, PaO2, PaCO2, hematocrit, blood volume and coagulation occurring after a rapid intra-aortic injection of a monomer and a dimer (salts of methylglucamine of the iothalamic and iocarmic acids) were compared. The effects of the monomer agreed with previous results but the effects of the dimer differed from those
Duc R, Barbe R, Amiel M
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High-performance liquid chromatographic determination of iothalamic acid in human plasma and urine
Journal of Chromatography B: Biomedical Sciences and Applications, 1991A simple, rapid and sensitive method for the determination of iothalamic acid (IA) in both plasma and urine is reported. After extraction with ethyl acetate, IA was determined by strong anion-exchange high-performance liquid chromatography with ultraviolet detection at 254 nm. The lower limit of detection was 0.5 micrograms/ml. The average recovery was
Giuseppe Remuzzi +3 more
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American Journal of Roentgenology, 1966
Two new concentrated contrast agents, MP 1005.2 and MP 2032, which are derivatives of iothalamic acid have been tested as angiographic contrast media. The results have been compared to results obtained with hypaque M-90; both of the new media proved to be less neurotoxic and nephrotoxic. Thus, in equivalent solutions iothalamate salts proved to be less
Robert A. Sewell +3 more
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Two new concentrated contrast agents, MP 1005.2 and MP 2032, which are derivatives of iothalamic acid have been tested as angiographic contrast media. The results have been compared to results obtained with hypaque M-90; both of the new media proved to be less neurotoxic and nephrotoxic. Thus, in equivalent solutions iothalamate salts proved to be less
Robert A. Sewell +3 more
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Journal of Pharmaceutical and Biomedical Analysis, 1994
A paired ion reversed-phase high performance liquid chromatographic method for simultaneous determination of iothalamic acid (Io) and para aminohippuric acid (PAH) in urine is described. The method uses a single internal standard for both drugs. The only sample preparation required is dilution of urine (1:100 or 1:500) with deionized water.
Ananda K. Seneviratne +2 more
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A paired ion reversed-phase high performance liquid chromatographic method for simultaneous determination of iothalamic acid (Io) and para aminohippuric acid (PAH) in urine is described. The method uses a single internal standard for both drugs. The only sample preparation required is dilution of urine (1:100 or 1:500) with deionized water.
Ananda K. Seneviratne +2 more
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Biopharmaceutics & Drug Disposition, 1986
AbstractThe oral absorption of iothalamate and the effect of amino acids on its absorption were studied in 6 dogs and 6 rats using a simple HPLC assay. The results showed that iothalamate was absorbed in dogs, averaging 9·9, 8·5, and 10·0 per cent following the administration of 40 and 100mg kg−1 of iothalamic acid capsules and 50mg kg−1 of sodium ...
Myung Gull Lee +3 more
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AbstractThe oral absorption of iothalamate and the effect of amino acids on its absorption were studied in 6 dogs and 6 rats using a simple HPLC assay. The results showed that iothalamate was absorbed in dogs, averaging 9·9, 8·5, and 10·0 per cent following the administration of 40 and 100mg kg−1 of iothalamic acid capsules and 50mg kg−1 of sodium ...
Myung Gull Lee +3 more
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Journal of Biomedical Materials Research, 1990
AbstractHighly porous poly(2‐hydroxyethyl methacrylate) (PHEMA) microspheres prepared by suspension polymerization of 2‐hydroxyethyl methacrylate (HEMA) in presence of polymeric diluents such as poly(methyl methacrylate) (PMMA) in toluene and poly(tetramethylene glycol) (PTMG) were made radiopaque by esterification of the reactive hydroxyl groups with ...
Mira Mohanty +3 more
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AbstractHighly porous poly(2‐hydroxyethyl methacrylate) (PHEMA) microspheres prepared by suspension polymerization of 2‐hydroxyethyl methacrylate (HEMA) in presence of polymeric diluents such as poly(methyl methacrylate) (PMMA) in toluene and poly(tetramethylene glycol) (PTMG) were made radiopaque by esterification of the reactive hydroxyl groups with ...
Mira Mohanty +3 more
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Journal of Liquid Chromatography, 1994
Abstract An ion paired reversed—phase high performance liquid chromatographic assay for iothalamic acid and para aminohippuric acid in the same sample of plasma is described. The analysis uses one internal standard for both drugs. Sample preparation consists of precipitating plasma proteins with methanol and centrifuging to settle the proteins.
John G. Gambertoglio +2 more
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Abstract An ion paired reversed—phase high performance liquid chromatographic assay for iothalamic acid and para aminohippuric acid in the same sample of plasma is described. The analysis uses one internal standard for both drugs. Sample preparation consists of precipitating plasma proteins with methanol and centrifuging to settle the proteins.
John G. Gambertoglio +2 more
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Journal of Chromatography A, 1994
A column-switching liquid chromatographic method for simultaneous determination of iothalamate and creatinine in human serum and urine was developed. Iothalamate and creatinine were separated on a weakly acidic ion-exchange column (C1) by ion-exclusion chromatography and iothalamate excluded from the column was purified by gel chromatography on a ...
Naohiko Ueda +5 more
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A column-switching liquid chromatographic method for simultaneous determination of iothalamate and creatinine in human serum and urine was developed. Iothalamate and creatinine were separated on a weakly acidic ion-exchange column (C1) by ion-exclusion chromatography and iothalamate excluded from the column was purified by gel chromatography on a ...
Naohiko Ueda +5 more
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