Results 41 to 50 of about 52,593 (263)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Comparison of networks simulators in IP networks

Математические машины и системы, 2014
?????? ???????????????????? ???????????????????????? ?? ?????????????? ???????????????????????? ?????????? ?????????????? ?????????????????????????????? ???????????????? ?????????????????????????? ?????????????????????? ?????? ???????????????? ???????? ?????? ????????????????????????. ???????????? ???????????? ????????????????????, ???????????????? ????
Davies, J., Comerford, P., Grout, V., Verovko, M., Stasiuk, S.   +4 more
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

MOBILITY MANAGEMENT STRATEGIES OF MOBILE IP NETWORKS

Electrica, 2006
In this paper, we give an overview of wireless Networks. Wireless networks provide voice and e-mail. In addition to these interactive multimedia and video conferencing.
Pınar KIRCI, A. Halim ZAIM
doaj   +2 more sources

Watching television over an IP network [PDF]

Proceedings of the 8th ACM SIGCOMM conference on Internet measurement, 2008
For half a century, television has been a dominant and pervasive mass media, driving many technological advances. Despite its widespread usage and importance to emerging applications, the ingrained TV viewing habits are not completely understood. This was primarily due to the difficulty of instrumenting monitoring devices at individual homes at a large
Meeyoung Cha, Pablo Rodriguez 0001, Jon Crowcroft, Sue B. Moon, Xavier Amatriain   +4 more
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Biological batch normalisation: How intrinsic plasticity improves learning in deep neural networks.

PLoS ONE, 2020
In this work, we present a local intrinsic rule that we developed, dubbed IP, inspired by the Infomax rule. Like Infomax, this rule works by controlling the gain and bias of a neuron to regulate its rate of fire. We discuss the biological plausibility of
Nolan Peter Shaw, Tyler Jackson, Jeff Orchard   +2 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

PERFORMANCE EVALUATION OF INTEGRATED MACRO AND MICRO MOBILITY PROTOCOLS FOR WIDE AREA WIRELESS NETWORKS [PDF]

ICTACT Journal on Communication Technology, 2010
The success of next generation wireless networks will rely much on advanced mechanisms for seamless mobility support among emerging heterogeneous technologies.
R.Gunasundari, A.R.Gunabarathy
doaj  

An analytical model for jitter in IP networks [PDF]

annals of telecommunications - annales des télécommunications, 2011
Traditionally, IP network planning and design is mostly based on the average delay or loss constraints which can often be easily calculated. Jitter, on the other hand, is much more difficult to evaluate, but it is particularly important to manage the QoS of real-time and interactive services such as VoIP and streaming video.
Hamza Dahmouni, André Girard, Brunilde Sansò   +2 more
openaire   +1 more source