Results 21 to 30 of about 1,471 (158)
Ipomoeassin-F disrupts multiple aspects of secretory protein biogenesis
Scientific Reports, 2021 The Sec61 complex translocates nascent polypeptides into and across the membrane of the endoplasmic reticulum (ER), providing access to the secretory pathway. In this study, we show that Ipomoeassin-F (Ipom-F), a selective inhibitor of protein entry into
Peristera Roboti +4 more
doaj +1 more source
Synthesis, Biological Evaluation and Docking Studies of Ring-Opened Analogues of Ipomoeassin F
Molecules, 2022 The plant-derived macrocyclic resin glycoside ipomoeassin F (Ipom-F) binds to Sec61α and significantly disrupts multiple aspects of Sec61-mediated protein biogenesis at the endoplasmic reticulum, ultimately leading to cell death.
Sarah O’Keefe +14 more
doaj +1 more source
Annals of the New York Academy of Sciences, Volume 1530, Issue 1, Page 161-181, December 2023., 2023 In this paper, we provide evidence that distinct regions within the periaqueductal gray (PAG) in songbirds may context‐specifically regulate song, agonistic, and courtship behaviors. These findings provide evidence for contributions from functionally distinct longitudinal columns to motivationally/affectively distinct songs and suggest that the ...
Chinweike N. Asogwa +5 more
wiley +1 more source
Asian Journal of Surgery, 2023 Purpose: The ideal surgical treatment of small ventral hernias (defect less than 4 cm) is still debatable. In our study, we sought to compare the outcomes of open versus laparoscopic intraperitoneal on-lay mesh (IPOM) repair in small ventral hernias ...
Clement Loh +8 more
doaj +1 more source
Limnology and Oceanography, Volume 68, Issue 10, Page 2346-2358, October 2023., 2023 Abstract Global warming causes dramatic environmental change to Arctic ecosystems. While pelagic primary production is initiated earlier and its intensity can be increased due to earlier ice melt and extended open‐water periods, sea‐ice primary production is progressively confined on a spatio‐temporal scale, leading to unknown consequences for the ice ...
Doreen Kohlbach +6 more
wiley +1 more source
A Biocompatible Dual‐Sided Hernia Mesh with Side‐Specific Properties
Advanced Materials Technologies, Volume 8, Issue 15, August 11, 2023., 2023 There is a considerable demand for hernia mesh, performing differently based on the specific requirements of its visceral and parietal sides. A novel technique is employed here for the first time to modify both the visceral and parietal sides of a mesh without compromising its porous structure, to impart low protein adsorption together with improved ...
Tanushree Saha +5 more
wiley +1 more source
Limnology and Oceanography, Volume 68, Issue 8, Page 1835-1851, August 2023., 2023 Abstract During the productive polar day, zooplankton and sea‐ice amphipods fulfill a critical role in energy transfer from primary producers to higher trophic‐level species in Arctic marine ecosystems. Recent polar night studies on zooplankton and sea‐ice amphipods suggest higher levels of biological activity than previously assumed.
Erin H. Kunisch +5 more
wiley +1 more source
Comparative analysis of innovative minimally invasive reconstructive techniques of abdominal-wall hernias: ventral TAPP versus laparoscopic IPOM [PDF]
, 2023 Die laparoskopische Reparation von Bauchwandbrüchen ist seit Jahren Bestandteil der Hernienchirurgie. Als Standardtechnik gilt das lap. IPOM Verfahren, welches sich aufgrund seiner vergleichsweise einfachen und standardisierten Operationstechnik sowie ...
Megas, Ioannis-Fivos
core +1 more source
Safety of laparoscopic repair of incisional hernias in liver transplant recipients
Clinical Transplantation, Volume 37, Issue 6, June 2023., 2023 Abstract Introduction Incisional hernia is a common complication following liver transplantation occurring in 5%–34% of patients. Traditionally, open repair was standard due to fear of abdominal adhesions, postoperative complications and lack of experience with laparoscopic techniques. Laparoscopic incisional hernia repair (LIHR) has now become routine
Isaac Vaughn Ealing +6 more
wiley +1 more source
Limnology and Oceanography, Volume 68, Issue 4, Page 862-877, April 2023., 2023 Abstract A rapidly warming Arctic Ocean and associated sea‐ice decline is resulting in changing sea‐ice protist communities, affecting productivity of under‐ice, pelagic, and benthic fauna. Quantifying such effects is hampered by a lack of biomarkers suitable for tracing specific basal resources (primary producers and microorganisms) through food webs.
Kim Vane +6 more
wiley +1 more source