Results 171 to 180 of about 492,305 (300)

Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields

Advanced Science, EarlyView.
Canonical Y‐shaped antibodies recognize viral glycan shields through adaptive Fab assembly states shaped by glycan organization and somatic hypermutation. Structural analyses ofbroadly neutralizing antibodies VRC35 and VRC36 across glycoproteins of HIV‐1, influenza, SARS‐CoV‐2, and Lassa viruses reveal distinct Fab assembly states, spanning monovalent,
Jiaxuan Cheng, Evan M. Cale, Amirabbas Maghsoudi, Matthew S. Sutton, Nancy S. Longo, Rebecca A. Gillespie, Lingshu Wang, Ivan Kosik, Sue Chong, Atsuhiro Yasuhara, Tatsiana Bylund, Arne Schön, Prabhanshu Tripathi, Yaroslav Tsybovsky, Haotian Lei, Nicholas C. Morano, Allison B. Lupatkin, Abraham J. Morton, Zabrina C. Lang, Jordan E. Becker, Isabella R. Frascilla, Myungjin Lee, Ning Li, Cuiping Liu, Ryan S. Roark, Chen‐Hsiang Shen, I‐Ting Teng, David J. Van Wazer, Danyi Wang, Lingyuan Wu, Goran Ahlsen, Mike Castro, Haijuan Du, Michael J. Ernandes, Tiansheng Li, Bob C. Lin, Mark K. Louder, Krisha McKee, Jonah S. Merriam, Sijy O'Dell, Li Ou, Sergei Pletnev, David Prikryl, Qi Qiu, Sarah Rubin, Mallika Sastry, Stephen D. Schmidt, Asif Shajahan, Andrea R. Shiakolas, Sanjay Srivatsan, Baoshan Zhang, Qiong Zhou, Mark Connors, Jason G. Gall, Yicheng Guo, Rick K. Huang, Yaoxing Huang, Richard A. Koup, Q. Paula Lei, John R. Mascola, Reda Rawi, Leonid Serebryannyy, Lawrence Shapiro, Zizhang Sheng, David D. Ho, Patrick C. Wilson, Jonathan W. Yewdell, Theodore C. Pierson, Masaru Kanekiyo, Nicole A. Doria‐Rose, Peter D. Kwong, Tongqing Zhou   +71 more
wiley   +1 more source

Prospective single-arm observational study evaluating a novel imaging device to assess anastomotic site mucosal oxygen tension and its association with anastomotic complications: study protocol. [PDF]

BMJ Open
Sherwani M, Ali D, Williams PJ, McChesney S, Ford MM, Hawkins AT, Muldoon R, Hopkins B, Geiger TM, Khan A.   +9 more
europepmc   +1 more source

Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy

Advanced Science, EarlyView.
This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo, Seon Min Woo, Minhyeong Choi, Soeun Rhee, Simmyung Yook, Donghyuk Shin, Kwang‐Su Park, Taeg Kyu Kwon   +7 more
wiley   +1 more source

A phase 3, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of vosoritide in children with hypochondroplasia: CANOPY HCH-3 study design. [PDF]

Ther Adv Endocrinol Metab
Dauber A, Savarirayan R, Carroll R, Cheung M, Cormier-Daire V, Maghnie M, Namba N, Semler O, Ghani S, Sabir I, Bassi R.   +10 more
europepmc   +1 more source

Monolayer MoS2 With Ultrahigh Piezoelectricity: From ALD Dose Control to Device Performance

Advanced Science, EarlyView.
This study demonstrates that controlling precursor dosages in atomic layer deposition (ALD) serves to regulate ultrathin oxide quality, which in turn determines sulfurization behavior and MoS2 monolayer continuity. The resulting continuous, low‐defect monolayers enable improved piezoelectric performance and support a flexible slippage sensor, linking ...
Yun Li, Ming Rui Joel Tan, Subhasis Das, Yafei Du, Wenjie Lai, Jiamin Amanda Ong, Yongli He, Yiming Zou, Anatoli Kurkin, Peiwen Huang, Jiajun Liu, Xingyu Chen, Alfred Iing Yoong Tok, Soo Jay Phee, Lioz Etgar, Shlomo Magdassi, Pooi See Lee   +16 more
wiley   +1 more source

Efficacy and safety of a novel semiautomated vitrification system for human blastocysts: a study protocol for a multicentre randomised controlled device trial with a live-birth extension study. [PDF]

BMJ Open
Wang S, Chen L, Chen L, Su Y, Sun H.
europepmc   +1 more source

CHST1 Drives Immunotherapy Resistance in Triple‐Negative Breast Cancer by Orchestrating an Immunosuppressive Microenvironment via the NKRF–CCL20–Macrophage Axis

Advanced Science, EarlyView.
Proposed model of CHST1‐associated immune remodeling in triple‐negative breast cancer. In CHST1‐low tumors, greater nuclear accumulation of NKRF is associated with repression of an NF‐κB‐related CCL20 transcriptional program and an immune‐inflamed microenvironment.
Shu‐Hao Jiang, Xiao‐Han Ying, Ruo‐Qing Wang, Qun Zhang, Li Chen, Zhi‐Ming Shao, Jun‐Jie Li   +6 more
wiley   +1 more source

The complete chloroplast genome of <i>Trachyspermum ammi</i> reveals a species-specific inverted repeat expansion. [PDF]

Front Plant Sci
Nagar R, Patial V, M S N, Choudhary S.
europepmc   +1 more source

Adolescent Sexual Behavior Research: Perspectives of Investigators, IRB Members, and IRB Staff about Risk Categorization and IRB Approval

, 2017
McGregor, Kyle A., Molnar, Elizabeth, Hensel, Devon J., Ott, Mary A., Waltz, Amy C.   +4 more
core   +1 more source

IRB Reform

, 2002
Slater, Eve E.
core   +1 more source