Results 41 to 50 of about 836,202 (311)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
‘Insufficient critique’ – The Oireachtas Banking Inquiry and the media
Administration, 2017 A parliamentary inquiry into the Irish banking collapse was formally established in November 2014, tasked with examining relevant issues from the period of January 1992 to December 2013.
Rafter Kevin
doaj +1 more source
Economic and Environmental Analysis of Small-Scale Anaerobic Digestion Plants on Irish Dairy Farms
Energies, 2020 The European Union’s (EU) climate and energy package requires all EU countries to reduce their greenhouse gas (GHG) emissions by 20% by 2020. Based on current trends, Ireland is on track to miss this target with a projected reduction of only 5% to ...
Sean O’Connor +4 more
doaj +1 more source
Prevalence of Drug Use and Gambling in Ireland and Drug Use in Northern Ireland - Bulletin 1
, 2016 8.11.2016 This Bulletin presents the key findings from the fourth drug prevalence survey of households in Ireland and Northern Ireland. Within Ireland the survey sampled a representative number of people aged 15+ from August 2014 to August 2015.
Department of Health (Ireland)
core +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Drug use in Ireland and Northern Ireland 2010/11 Drug Prevalence Survey: Cannabis Results Bulletin 3
, 2013 This bulletin presents findings regarding the use of cannabis in Ireland from the third drug prevalence survey of households in Ireland and Northern Ireland.
Department of Health (Ireland)
core +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Journal of Lithic Studies, 2016 The LIR (Lithotheque Ireland) reference collection of flaked stone tool raw materials from Ireland began in 2013, and is based on the geological prospection from two projects. The first (2013-2015) focused attention primarily on Carboniferous cherts from
Killian Driscoll +2 more
doaj +1 more source
The changing map of subnational governance in the Republic of Ireland
Administration, 2021 The evolution of the territorial structure of Ireland’s system of local government during the period of colonial rule by England is outlined. The independence period saw little change in this structure until the abolition of municipal-level government in
Breathnach Proinnsias +2 more
doaj +1 more source
Links between Smoking, E-cigarette and Cannabis use, and Gambling in Ireland: What are the odds?
Tobacco Prevention and Cessation, 2023 Introduction Links between teenage gambling and tobacco and cannabis use have been reported for more than 25 years 1 . Less is known about e-cigarette use and gambling. In Ireland, data about teenage smoking, cannabis use and gambling have been available
Joan Hanafin +4 more
doaj +1 more source