Results 171 to 180 of about 330,930 (279)

CXCR6+ T cells promote apoptosis and necroptosis in proximal tubules during AKI-to-CKD transition. [PDF]

Cell Death Dis
Li X, Melchinger I, Chen Y, Guo J, Cantley LG, Xu L.   +5 more
europepmc   +1 more source

FOLFIRINOX vs. Gemcitabine/Nab‐Paclitaxel for Pancreatic Cancer by BRCA2 and TMB Status: A Japanese C‐CAT Database Study

Cancer Science, Volume 117, Issue 5, Page 1422-1433, May 2026.
In a large real‐world C‐CAT cohort of unresectable or recurrent pancreatic cancer, we evaluated outcomes with first‐line FOLFIRINOX versus gemcitabine/nab‐paclitaxel by BRCA2 pathogenic variant and TMB status. Survival was more strongly associated with therapeutic sequencing than the initial regimen, supporting early molecular profiling to optimize the
Kazuyuki Mizuno, Takuya Ishikawa, Takanori Ito, Yuko Takano, Osamu Maeda, Hiroki Kawashima, Yuichi Ando   +6 more
wiley   +1 more source

Increased Urinary Albumin Excretion But Less Damaged Renal Tubular Structures in Mice with Genetically Decreased <i>Elmo1</i> Post Ischemia/Reperfusion Injury. [PDF]

Innov Discov
Chen M, Ma Q, Wariyapperuma Appuhamillage NMW, Wang Y, Kayashima Y, Maeda-Smithies N, Li F.   +6 more
europepmc   +1 more source

Proteomic Trajectories of Metabolic and Proteostatic Adaptation During Normothermic Liver Perfusion

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background Normothermic machine perfusion (NMP) enables metabolic restoration and viability testing of liver grafts, but current viability criteria incompletely predict post‐transplant outcomes. The molecular basis of graft resilience or biliary vulnerability remains unclear. This study aimed to characterise tissue‐level proteomic trajectories
Heithem Jeddou, Anne‐Aurélie Raymond, Jean‐William Dupuy, Cyril Dourthe, Hector Prudhomme, Eya Ben Nejma, Stylianos Tzedakis, Bruno Turlin, Pierre Allaume, Karim Boudjema, Michel Samson   +10 more
wiley   +1 more source

PANoptosis nexus in ischemia-reperfusion injury: from integrated cell death mechanisms to novel therapeutic opportunities. [PDF]

Front Immunol
Chen H, Men J, Gao T, Ma F, Jia Z.
europepmc   +1 more source

Insights Into Remote Ischemic Conditioning miRNA Effects on Brain Endothelial Cells During Ischemia–Reperfusion

Microcirculation, Volume 33, Issue 4, May 2026.
ABSTRACT Objective Acute ischemic stroke (AIS) is one of the leading causes of death and disabilities, and as such, it is of utmost importance to identify novel treatment options. Remote ischemic conditioning (RIC) is a promising non‐invasive treatment that is thought to activate the body's own protective mechanisms against damaging ischemia.
Katrine Tang Stenz, Jesper Just, Zenghui Huang, Thomas Ravn Lassen, Kristian Vissing, Xiu‐Jie Wang, Kim Ryun Drasbek   +6 more
wiley   +1 more source

Estradiol and Raloxifene Protect Ovariectomized Mice from Acute Kidney Injury via G Protein-Coupled Estrogen Receptor-Mediated Nuclear Factor Erythroid 2-Related Factor 2/Heme Oxygenase-1 Activation. [PDF]

Int J Mol Sci
Wang Y, Song Y, Dai J, Zhang X, Zhao L, Mao Y, Ding M.   +6 more
europepmc   +1 more source

Mechanisms for Decadal Variability of Ocean Heat Uptake Inferred From Adjoint Sensitivities

Geophysical Research Letters, Volume 53, Issue 8, 28 April 2026.
Abstract The occurrence of a period of slowdown in surface air temperature increase from 1998 to 2013 despite continued greenhouse gas emissions (the warming hiatus) has suggested that ocean heat uptake (OHU) is susceptible to decadal variability. Here, we identify mechanisms that lead to decadal changes in OHU to revisit the origin of the warming ...
Armin Köhl, Chavely Albert Fernández
wiley   +1 more source

Can the International Reference Ionosphere Model Predict Long‐Term Trends in the Ionosphere?

Geophysical Research Letters, Volume 53, Issue 8, 28 April 2026.
Abstract The International Reference Ionosphere (IRI) model can partially reproduce ionospheric long‐term trends (LTTs), although not intentionally, provided that an appropriate effective ionospheric index is used. We evaluate how model predictions driven by a solar activity proxy (R12) and by an effective ionospheric proxy (IG12) can reproduce the ...
A. Pignalberi, M. Pietrella, T. Alberti, M. Pezzopane   +3 more
wiley   +1 more source

Suppression of Glucosylceramide Synthase Reverses Drug Resistance in Cancer Cells Harboring Homozygous p53 Mutants. [PDF]

Int J Mol Sci
Mostaq MS, Amin MN, Raphael A, Asbury C, Gupta A, Gu X, Han X, Sekulic D, Michalak P, Kang L, Liu YY.   +10 more
europepmc   +1 more source