Results 11 to 20 of about 5,279 (188)

An Autopsy Case With Fragile X-Associated Tremor/Ataxia Syndrome Presenting Intranuclear Inclusion Bodies Mainly in the Limbic System. [PDF]

Neuropathology
ABSTRACT Fragile X‐associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder characterized by a late onset and slow progression caused by a premutation (55–200 CGG repeat) in the fragile X mental retardation (FMR1) gene. Here, we report the case of a Japanese patient with FXTAS which is the first case autopsied in Japan. The patient was
Shioya A, Ishii K, Sato T, Noguchi M, Tamaoka A, Saito Y.   +5 more
europepmc   +2 more sources

Immunohistochemical Analysis of Tom20 in Choroid Plexus Epithelial Cells From Elderly Brains With Neurodegenerative Diseases. [PDF]

Neuropathology
ABSTRACT The choroid plexus (CP) contributes to cerebrospinal fluid (CSF) production and regulation of circadian rhythm. Recently, many neuroimaging studies have reported enlarged CP volumes in patients with neurodegenerative diseases, including Alzheimer's disease (AD).
Murakami R, Chiba Y, Miyai Y, Matsumoto K, Wakamatsu K, Saito Y, Hara M, Murayama S, Ueno M.   +8 more
europepmc   +2 more sources

IgE to cyclophilin Bet v 7 triggers mast cell activation and mediates cross-reactivity with Ara h 18 in children with seasonal allergic rhinitis. [PDF]

Pediatr Allergy Immunol
Abstract Background Panallergens are ubiquitously expressed molecules that may drive IgE sensitization across diverse allergen sources, thereby shaping complex clinical phenotypes such as asthma and pollen–food allergy syndrome (PFAS). Although several panallergen families have been extensively characterized, unexplained sensitization patterns are ...
Sponholz W, Steinert C, Monnati F, Potapova E, Lidholm J, Mattsson L, Scala E, Bernardini R, Caffarelli C, Casani A, Cervone R, Del Duca E, Comberiati P, De Castro G, Del Giudice MM, Iacono ID, Businco ADR, Gallucci M, Giannetti A, Moschese V, Varin E, Bianchi A, Calvani M, Frediani T, Macrì F, Maiello N, Paravati F, Pelosi U, Peroni D, Pingitore G, Tosca M, Zicari AM, Ricci G, Asero R, Tripodi S, Matricardi PM, Scheffel J.   +36 more
europepmc   +2 more sources

A Novel Neuropathological Subtype of Amyotrophic Lateral Sclerosis Characterised by Prominent Astroglial TDP-43 Pathology. [PDF]

Neuropathol Appl Neurobiol
Neuropathology and Applied Neurobiology, Volume 51, Issue 5, October 2025.
Matsubara T, Izumi Y, Hatanaka Y, Takahara M, Kondo A, Matsukura K, Arakawa A, Haga T, Miyamoto R, Naruse H, Morino H, Toda T, Murayama S, Saito Y.   +13 more
europepmc   +2 more sources

Simple screening models for cognitive impairment in community settings: The IRIDE Cohort Study. [PDF]

Geriatr Gerontol Int, 2022
Aim Community settings often need simple screening, rather than detailed tests, to identify cognitive impairment. This study aimed to develop models to screen older adults with cognitive impairment. Methods This study used data from the Integrated Research Initiative for Living Well with Dementia Cohort Study and included 5830 older adults. Individuals
Abe T, Kitamura A, Yamashita M, Kim H, Obuchi SP, Ishizaki T, Fujiwara Y, Awata S, Toba K, IRIDE Cohort Study investigators.   +9 more
europepmc   +2 more sources

Morphometry of choroid plexus epithelial cells in neurodegenerative diseases. [PDF]

Neuropathology
The choroid plexus not only secretes the majority of cerebrospinal fluid but also controls the circadian rhythm, which can be impaired in the presence of neurodegenerative diseases. In addition, many studies have reported the contribution of choroid plexus abnormalities to the pathogenesis of neurodegenerative diseases, including Alzheimer's disease ...
Murakami R, Chiba Y, Miyatake N, Miyai Y, Matsumoto K, Wakamatsu K, Saito Y, Hara M, Murayama S, Ueno M.   +9 more
europepmc   +2 more sources

Applications of artificial intelligence in dementia. [PDF]

Geriatr Gerontol Int
We introduce the research on AI utilization in dementia, which can lead us to a better world. The recent evolution of artificial intelligence (AI) can be considered life‐changing. In particular, there is great interest in emerging hot topics in AI such as image classification and natural language processing.
Kameyama M, Umeda-Kameyama Y.
europepmc   +2 more sources

Mosaic variants of neurodevelopmental and mitochondrial genes in postmortem paraventricular thalamus in bipolar disorder detected by deep exome sequencing. [PDF]

Psychiatry Clin Neurosci
Aim The genetic architecture of bipolar disorder (BD) remains incompletely understood despite extensive genomic studies. Postzygotic mosaic variants have emerged as promising contributors to BD; however, the landscape of such variants in the BD brain has yet to be elucidated.
Nishioka M, Tanei ZI, Saito Y, Morishima M, Hino M, Mori K, Nagaoka A, Shishido R, Saito R, Kitamura H, Nagakura A, Kimura A, Iritani S, Oshima K, Kakita A, Kunii Y, Murayama S, Kato T.   +17 more
europepmc   +2 more sources

Maximizing Societal Benefit Across Multiple Hyperspectral Earth Observation Missions: A User Needs Approach

Journal of Geophysical Research: Biogeosciences, Volume 128, Issue 12, December 2023., 2023
Abstract Imaging spectroscopy is a powerful tool used to support diverse Earth science and applications objectives, ranging from understanding and mitigating widespread impacts of climate change to management of water at farm‐scale. Community studies, such as those deployed by NASA's Surface Biology and Geology and ESA's Copernicus Hyperspectral ...
Emma Schiavon, Andrea Taramelli, Antonella Tornato, Christine M. Lee, Jeffrey C. Luvall, Stephanie Schollaert Uz, Philip A. Townsend, Valentina Cima, Serena Geraldini, Alessandra Nguyen Xuan, Emiliana Valentini, Charles E. Miller   +11 more
wiley   +1 more source

Varietal identification in pasta through an SSR‐based approach: a case study

Journal of the Science of Food and Agriculture, Volume 103, Issue 11, Page 5521-5528, 30 August 2023., 2023
Abstract BACKGROUND Pasta is a worldwide popular Italian food made exclusively of durum wheat. The choice of variety to be used to produce pasta is at the discretion of the producer based on the peculiar characteristics of each cultivar. The availability of analytical approaches for the tracking of specific varieties along the productive chain is ...
Valentina Fanelli, Maria Dellino, Francesca Taranto, Claudio De Giovanni, Wilma Sabetta, Pasquale De Vita, Cinzia Montemurro   +6 more
wiley   +1 more source