Results 31 to 40 of about 3,805,826 (291)

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

SciTools/iris: Iris 1.12.0

, 2017
<p><a href="http://scitools.org.uk/iris/docs/v1.12.0/index.html">http://scitools.org.uk/iris/docs/v1.12.0/index.html</a></p> <p><a href="http://scitools.org.uk/iris/docs/v1.12.0/whatsnew/1.12.html">http://scitools.org ...
Stephan Hoyer, kwilliams-mo, Ed Campbell, Jozhogg, Bill Little, David Murray, Phil Elson, Elliott Sales de Andrade, Corinne Bosley, Niall Robinson, Daniel Kirkham, marqh, Emma Hogan, Peter Killick, lbdreyer, Ruth Comer, Patrick Peglar, Armin Leuprecht, scmc72, Andrew Dawson, dannymet97, Richard Hattersley, Ian Edwards, Carwyn Pelley, munslowa, Byron Blay, Filipe, Andreas Hilboll, Jon Seddon, Phil Bentley, Jamie Kettleborough   +30 more
core   +2 more sources

IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME IN HIV INFECTION

Инфекция и иммунитет, 2018
Antiretroviral therapy (ART) leads to suppression of HIV replication, contributes to increase in the number of CD4-lymphocytes count and  partial restoration or activation of the immune system.
E. V. Boeva, N. A. Belyakov
doaj   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Escherichia coli K1 meningitis concomitant with septic arthritis in an adult: a rare case and mini-review of the literature

New Microbes and New Infections
Background: Meningitis caused by Escherichia coli K1 occurs only in specific cases: in neonates or in adults following trauma or in a nosocomial context resulting from procedures that create a direct entry point, such as neurosurgical procedures ...
Marie Tré-Hardy, Sophie Collignon, Andrea Della Vecchia, Mikael Leys, Roberto Cupaiolo, Ingrid Beukinga, Denis Piérard, Florence Crombé, Laurent Blairon   +8 more
doaj   +1 more source

Tuberculosis IRIS: Pathogenesis, Presentation, and Management across the Spectrum of Disease [PDF]

Life, 2020
Antiretroviral therapy (ART), while essential in combatting tuberculosis (TB) and HIV coinfection, is often complicated by the TB-associated immune reconstitution inflammatory syndrome (TB-IRIS). Depending on the TB disease site and treatment status at ART initiation, this immune-mediated worsening of TB pathology can take the form of paradoxical TB ...
Carson M. Quinn, Victoria Poplin, John Kasibante, Kyle Yuquimpo, Jane Gakuru, Fiona V. Cresswell, Nathan C. Bahr   +6 more
openaire   +3 more sources

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Study on Iris Segmentation Algorithm Based on Dense U-Net

IEEE Access, 2019
Iris segmentation is an essential process of iris recognition. Iris segmentation plays an important role in maintaining the accuracy of iris based on recognition system by limiting the errors in the current stage.
Xiaoqiang Wu, Long Zhao
doaj   +1 more source

Microglial TSPAN4‐Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune‐Vascular Crosstalk

Advanced Science, EarlyView.
Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu, Jingfan Wang, Pengfei Ge, Qinyuan Gu, Hongying Li, Yuanyuan Fan, Haiyue Xie, Yangyang Lu, Yifan Lin, Xinjing Wu, Chengkun Wang, Ping Xie, Zizhong Hu   +12 more
wiley   +1 more source