Results 211 to 220 of about 10,618,925 (346)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

New investigations of the Hjortspring boat: Dating and analysis of the cordage and caulking materials used in a pre-Roman iron age plank boat. [PDF]

PLoS One
Fauvelle M, Bengtsson B, Pipping O, Hollmann M, Mortensen MN, Toft P, Ganji S, Green A, Horn C, Hall S, Kaul F, Ling J.   +11 more
europepmc   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

La restitution 3D et l’étude architecturale des bâtiments à parois rejetées en région Centre aux iie-ier s. avant notre ère

Archéopages, 2013
Gaëlle Robert, Nicolas Holzem
doaj   +1 more source

Late Iron Age and Roman equine breeding north of the Alps: Genetic insights and cultural implications. [PDF]

iScience
Sharif MB, Mohaseb AF, Orlando L, Saliari K, Kunst GK, Czeika S, Mashkour M, Cucchi T, Peters J, Trixl S, Mohandesan E.   +10 more
europepmc   +1 more source

Woodland modification in Bronze and Iron Age central Anatolia: an anthracological signature for the Hittite state?

, 2015
N. Wright, Andrew S. Fairbairn, J. Faith, K. Matsumura   +3 more
semanticscholar   +1 more source

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

Iron Mineralization of Textiles from Iron Age Burial Sites in Slovenia

reservedAncient textiles made of natural materials, such as cellulosic and protein-based fibers, are rarely preserved in archeological contexts, unless specific conditions are met that would contribute to their preservation.
MOTTA VIERA, ALEJANDRA SOFIA
core  

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Innovation through recycling in Iron Age plaster technology at Tell el-Burak, Lebanon. [PDF]

Sci Rep
Amicone S, Orsingher A, Cantisani E, Calandra S, Badreshany K, Spiteri C, Berthold C, Sader H, Schmitt A, Kamlah J.   +9 more
europepmc   +1 more source