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A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced Cardiotoxicity

open access: yesAdvanced Science, EarlyView.
In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo   +19 more
wiley   +1 more source

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

open access: yesAdvanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa   +23 more
wiley   +1 more source
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The future iron age

Nature Chemistry, 2020
Recent research has shown that vibronic coherences are one of the primary drivers for ultrafast light-induced processes. Now, ultrafast spectroscopy has been used to uncover vibronic coherences in the excited-state dynamics of an iron complex, leading to its redesign and the drastic prolonging of its excited-state lifetime.
openaire   +2 more sources

Iron Age Pottery

Proceedings of the Prehistoric Society, 1985
Fabric categories.Fabric 1 : flint tendered (28%)Inclusions; medium size calcined flint temper of medium abundance (approximately 1000 grains per 1 gm of sherd) with a negligible backing of medium grade sand quartz natural to the clay.Example of analysed sherd: flint temper (99%0; G - 0.9%, VC - 8#5%, C - 26.8%, M - 39.4%, F - 24.4% quartz sand (1%); M
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The Iron Age

2002
European archaeologists formulated the idea of an Iron Age early in the nineteenth century, as they began organizing the growing collections of antiquities in museums then being established in different parts of the continent (Kuhn 1976). Changes in agricultural technology and the large-scale earth-moving connected with the construction of railroads ...
openaire   +1 more source

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