Results 111 to 120 of about 5,171 (202)

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Analytical Methodology to Determine Thermally Induced Soil Deformation From Laboratory Data

open access: yesInternational Journal for Numerical and Analytical Methods in Geomechanics, EarlyView.
ABSTRACT Experimental laboratory investigations underlie most of the knowledge about the mechanics of soils under non‐isothermal conditions and their thermally induced deformation. Despite advances, the understanding of thermally induced deformation of soils remains inconsistent, hindering the development of a coherent framework that can advance ...
Jibril B. Coulibaly   +1 more
wiley   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva   +10 more
wiley   +1 more source

Phytoplankton dynamics shape bacterioplankton community structure and metabolism during the austral summer-autumn transition in the Western Antarctic Peninsula. [PDF]

open access: yesFEMS Microbiol Ecol
Pavlovska M   +9 more
europepmc   +1 more source

Impact of Packaging and Recycling Systems on Material Recirculation: A Stage‐Decomposition Model

open access: yesPackaging Technology and Science, EarlyView.
A system‐level view emerges from decomposing recycling into four stages (participation, collection, sorting and process yield), diagnosing constraints and targeting interventions. Cumulative equivalent uses (CEUs) quantify long‐term retention, revealing marginal improvements at high baselines generate disproportionately larger gains than low‐baseline ...
Diogo Figueirinhas   +3 more
wiley   +1 more source

Lightning electromagnetic emission location using arrival time differencing (LEELA): An introduction to the Met Office's next generation Very Low Frequency lightning location system

open access: yesQuarterly Journal of the Royal Meteorological Society, EarlyView.
This paper describes the Met Office's new lightning location system LEELA. A brief overview of the upgraded hardware and geolocation algorithms is given. LEELA has improved lightning detection capabilities, especially at night. When comparing LEELA to the previous ATDnet system against ground truths LEELA has 100% storm detection efficiency within 5 km
Graeme Marlton   +7 more
wiley   +1 more source

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