Results 51 to 60 of about 20,343,435 (287)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Minimum Dissipation Principle in Nonlinear Transport

Entropy, 2015
We extend Onsager’s minimum dissipation principle to stationary states that are only subject to local equilibrium constraints, even when the transport coefficients depend on the thermodynamic forces.
Giorgio Sonnino, Jarah Evslin, Alberto Sonnino   +2 more
doaj   +1 more source

Incremental least action principle in the framework of thermodynamics of irreversible processes

Physical Review Research, 2020
In this paper, an incremental least action principle is proposed using the framework of the thermodynamics of irreversible processes. First, we establish that an extensive thermodynamic potential defined over an infinitesimal volume satisfies a ...
V. Magnenet, J. Schmittbuhl
doaj   +1 more source

Maximum work output configuration of finite potential source irreversible isothermal chemical engines with bypass mass leakage and mass resistance

Energy Reports, 2022
A model of a finite potential source irreversible isothermal chemical engine (ICE) cycle with bypass mass leakage and mass resistance is established. Mass transfer processes are assumed to obey linear mass transfer law [g∝Δ(μ)] in linear irreversible ...
Lingen Chen, Shaojun Xia
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Violation of thermodynamic speed limits as a criterion for physical model selection

Machine Learning: Science and Technology
Machine learning algorithms are now being used to automate the discovery of physical equations from measurement data. However, under or overfitting the dynamics can lead to model misspecification and unreliable predictions.
Shiqi Chen, Jason R Green
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Entropy Production and Irreversible Processes -from the perspective of continuous topological evolution.

Entropy, 2004
: A concept of entropy production associated with continuous topological evolution is deduced (without statistics) from the fact that Cartan-Hilbert 1-form of Action defines a non-equilibrium symplectic system of Pfaff Topological dimension 2n+2.
Robert M. Kiehn
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source