Results 81 to 90 of about 1,916 (169)

R‐Loops Mediated Odontogenic Differentiation of hDPSCs by Activating the cGAS‐STING Pathway Under Inflammatory Microenvironment

Oral Diseases, EarlyView.
ABSTRACT Background R‐Loops are three‐stranded DNA/RNA hybrids implicated in immune responses. Their role in mesenchymal stem cell differentiation, particularly in dental pulp regeneration under inflammation, remains unclear. Methods Rat pulpo‐dentinal complex (PDC) injury models and LPS‐stimulated human dental pulp stem cells (hDPSCs) were used.
Yun Yang, Yiqing Wang, Yating Miao, Zhipu Luo, Lin Niu, Ruirui Liu   +5 more
wiley   +1 more source

Advantages of horizontal centrifugation of platelet‐rich fibrin in regenerative medicine and dentistry

Periodontology 2000, EarlyView.
Abstract The aim of this comprehensive review was to evaluate comparative studies on horizontal and fixed‐angle centrifugation methods for preparing platelet‐rich fibrin (PRF). Furthermore, additional studies utilizing horizontal PRF (H‐PRF) were systematically investigated.
Nima Farshidfar, Karol Alí Apaza Alccayhuaman, Nathan E. Estrin, Paras Ahmad, Anton Sculean, Yufeng Zhang, Richard J. Miron   +6 more
wiley   +1 more source

Antibiotics do not reduce toothache caused by irreversible pulpitis [PDF]

Evidence-Based Dentistry, 2005
Cochrane Oral Health Group Trials Register and the Pain, Palliative Care and Supportive Care Group Trials Register, the Cochrane Central Register of Controlled Trials, Medline and Embase.Randomised controlled trials (RCT) were included that involved patients over the age of 18 years who had presented with a single tooth with a clinical diagnosis of ...
openaire   +2 more sources

Pulpitis irreversible como forma de presentación de un odontoma

, 2015
Se presenta un caso de odontoma compuesto que provocó pulpitis irreversible en el incisivo central superior derecho (1,1) en una joven de 20 años.
Berástegui, Esther, Buenechea Imaz, Ramón   +1 more
core   +1 more source

Comparative evaluation of platelet-rich fibrin, mineral trioxide aggregate, and calcium hydroxide as pulpotomy agents in permanent molars with irreversible pulpitis: A randomized controlled trial

Contemporary Clinical Dentistry, 2016
Background: Pulpotomy has been proposed as an alternative for the management of irreversible pulpitis in permanent molars with closed apices. Aim: To compare the performances of calcium hydroxide (CH), mineral trioxide aggregate (MTA), and platelet-rich ...
Varun Kumar, Ruchi Juneja, Jigyasa Duhan, Pankaj Sangwan, Sanjay Tewari   +4 more
doaj   +1 more source

Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to Streptococcus mutans: A Bulk RNA‐Seq Analysis

International Endodontic Journal, Volume 59, Issue 7, Page 1402-1415, July 2026.
ABSTRACT Aim The dental pulp is an immunologically active tissue that responds dynamically to cariogenic challenge. Peripheral pulp cells adjacent to dentine encounter bacterial stimuli earlier than cells located in the central pulp. To investigate signalling and immune interactions, this study profiled the transcriptomes of dentine‐adherent cells ...
Sandra Pohl, Maximilian L. Huber, Tobias Akamp, Andreas Rosendahl, Melanie Linnebank, Lea Schreiber, Claudia Gebhard, Nicholas Strieder, Michael Rehli, Wolfgang Buchalla, Matthias Widbiller   +10 more
wiley   +1 more source

Expression of calcitonin gene-related peptide and pulp sensitivity tests in irreversible pulpitis

, 2019
The aim of the present study was to identify the relationship between the expression of calcitonin gene-related peptide (CGRP) and the responses of pulp sensitivity tests in healthy pulps and irreversible pulps by performing a cross-sectional study on ...
Gabriel Alejandro MARTÍNEZ- CASTAÑÓN (7368692), Brenda Eréndida CASTILLO-SILVA (7368686), Nuria PATIÑO-MARÍN (7368707), Eva Concepción AGUIRRE-LÓPEZ (7368698), Jesús Ramón CASTILLO-HERNÁNDEZ (7368701), Nereyda NIÑO-MARTÍNEZ (7368704), Carlo Eduardo MEDINA-SOLÍS (7368695), Verónica MARTÍNEZ-JIMÉNEZ (7368689)   +7 more
core   +1 more source

Deep Caries Management: EFCD‐ESE‐ORCA S3‐Level Clinical Practice Guideline

International Endodontic Journal, Volume 59, Issue 7, Page 1298-1315, July 2026.
ABSTRACT Objective To develop an evidence‐based S3‐level clinical practice guideline for the management of deep and extremely deep caries in vital permanent teeth. Methods An evidence‐based medical guideline based on systematically searched and appraised evidence as well as a structured consensus (S3‐level) was jointly developed by the European ...
Falk Schwendicke, Esra Kosan, Avijit Banerjee, Aylin Baysan, Lars Bjørndal, Laura Ceballos, Henry F. Duncan, Sascha Herbst, Klaus W. Neuhaus, Anne C. O'Connell, Sebastian Paris, Helena Dujic   +11 more
wiley   +1 more source

The Role of the Kynurenine Pathway in Irreversible Pulpitis

Journal of Dental Research
Current therapeutic practices have limited effectiveness at targeting acute pain locally. This is in part due to the lack of understanding of the neuroinflammatory pathways active within pulpitis. Increased activity of inadoleamine 2,3 dioxygenase (IDO) was linked to hypersensitivity and pain in several settings.
J. Coulter, C.J. Nile, H. Lemos, P. LoCoco, J. Whitworth, R.A. Valentine, A. Diogenes, C. Chang, A. Mellor, V. Telezhkin, J. Durham   +10 more
openaire   +1 more source

Factors Associated With the Citation Impact of Evidence Synthesis Reviews in Endodontics: A Bibliometric Analysis

International Endodontic Journal, Volume 59, Issue 7, Page 1384-1401, July 2026.
ABSTRACT Background Systematic reviews are essential for evidence‐based decision‐making in endodontics, and their number has grown substantially in recent years. However, little is known about the publication patterns, methodological features and citation impact of these studies.
Rafaella Rodrigues da Gama, Lucas Peixoto de Araújo, Melissa Feres Damian, Wellington Luiz de Oliveira da Rosa   +3 more
wiley   +1 more source