Results 191 to 200 of about 122,882 (298)

Frustration Induction Alters Reward Prediction Error Encoding in Pediatric Irritability

Background Irritability is a prevalent, impairing, transdiagnostic affective symptom domain in youth associated with elevated risk for adverse outcomes. Theoretical models of irritability implicate disruptions in reward learning and frustrative nonreward.
Lili Massac, Diana Burk, Sofia I .Cárdenas, Ellie P. Xu, Daniel S. Pine, Simone Haller, Bruno B. Averbeck, Ellen Leibenluft, Jennifer Meigs, Katharina Kircanski, Yannie D. Lee, Caroline M. Miller, Tahjanee Givens, Melissa A. Brotman, Hong N.T. Bui, Gretchen R. Perhamus, Marta Korom, Michal Clayton   +17 more
core  

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Clinical Use of Valproate and Divalproex in Autism Spectrum Disorder: A Systematic Review of Efficacy and Safety. [PDF]

Cureus
Hridhey F, Gupta N, Khurana P, Miller V, Gupta M.   +4 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Long-Term Follow-Up of Levetiracetam Monotherapy Versus Add-On Therapy in Pediatric Epilepsy. [PDF]

Children (Basel)
Osada Y, Nakano K, Nakakuni M, Tsuchiya J, Watanabe M, Kobayashi S, Akabane M, Yamamoto Y, Yamatani A.   +8 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Frustrative non-reward: A cross-species probe to study brain mechanisms of irritability. [PDF]

Transl Psychiatry
Tseng WL, Li Z, Leibenluft E.
europepmc   +1 more source

ATROPINE IRRITATION [PDF]

British Journal of Ophthalmology, 1938
openaire   +2 more sources

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Irritating patients, irritated dentist [PDF]

Vital, 2006
openaire   +1 more source