Results 181 to 190 of about 62,917 (336)

PVC Nanoplastics Exposure Exacerbates Asthma through R‐Loop Accumulation and Subsequent STING Activation in Macrophages

Advanced Science, EarlyView.
Polyvinyl chloride (PVC) nanoplastics (NPs) are shown to aggravate allergic airway inflammation in asthma by triggering R‐loop accumulation and activating the cGAS‐STING pathway in macrophages. This study reveals a novel immunotoxic mechanism linking environmental plastic exposure to asthma pathogenesis and highlights potential molecular targets for ...
Qimei Bao, Yixing Huang, Mingcong Deng, Chunkai Zhang, Dan Zu, Hanyi He, Yangchan Hu, Yuke Zhong, Chen Liang, Haidong Liu, Wumin Dai, Yanhua He, Yaoshu Teng, Ji Jing, Yin Shi, Xiangdong Cheng, Zu Ye   +16 more
wiley   +1 more source

Capacitive Biosensing of Skin Irritants Using a Lanolin-Based Artificial Stratum Corneum Model. [PDF]

Biosensors (Basel)
Cheng CT, Kung Y, Chen HY, Chang KH, Chen RLC, Cheng TJ.   +5 more
europepmc   +1 more source

The Influence of Some Irritant Chemicals and Scarification on Tumour Initiation by Urethane in Mice

, 1963
A. W. Pound, H.R. Withers
openalex   +2 more sources

Continuous Suppression of Pathological Retinal and Choroidal Neovascularization in Cynomolgus Monkeys via Noninvasive Ophthalmic Delivery of a Novel Anti‐VEGFA Nanobody and Proprietary Penetratin Analog Formulation

Advanced Science, EarlyView.
Pathological retinal/choroidal neovascularization drives vision loss in DR and AMD. Current anti‐VEGF injections, while effective, require invasive, frequent administration. Pene/LQ015, is developed a novel topical anti‐VEGFA nanobody formulation achieving therapeutic intraocular levels through penetratin analog‐enhanced delivery.
Chong Chen, Min Zhu, Xingyan Fan, Kangjia Lv, Kuan Jiang, Yuchen Zhang, Haoliang Zhang, Xinming Qi, Benjamin TK Lee, Yakun Wan, Gang Wei, Kun Liu, Xun Xu   +12 more
wiley   +1 more source

Irritant Contact Dermatitis Induced by Compound Clobetasol Propionate in a Patient with Undiagnosed Type 2 Diabetes Mellitus. [PDF]

Clin Cosmet Investig Dermatol
Ge X, Hao P, Chen X.
europepmc   +1 more source

Sulphan Blue as an Aid to the Laboratory Assessment of Primary Skin Irritants**From “Shell” Research Limited, Tunstall Laboratory, Sittingbourne, Kent, England.

, 1965
V. K. H. Brown, Richard Clarke
openalex   +1 more source

KLK1 as an Epithelial‐Specific Brake Inhibits Colorectal Tumorigenesis by Suppressing B1R‐Mediated Fibroblast Phenotypic Transition

Advanced Science, EarlyView.
KLK1 downregulation disrupts the intestinal mucosal barrier and impairs kallikrein‐kinin signaling, thereby reducing Lys‐des‐Arg9‐BK production. This enhances B1R activation on ADAMDEC1⁺ fibroblasts, promoting inflammation and extracellular matrix (ECM) remodeling. The resulting iCAFs promote colorectal cancer progression, highlighting a novel KLK1‐B1R
Lisha Zhou, Meijing Wang, Shunji Liu, Limei Gu, Shijia Liu, Qianming Du, Tianyi Zhang, Yinuo Ma, Lixin Zhao, Jiaming Wang, Qiang Xu, Tingsheng Ling, Haibo Cheng, Hongqi Chen, Yang Sun   +14 more
wiley   +1 more source

Multicenter questionnaire study investigating characteristics of adults with unexplained chronic cough versus explained chronic cough. [PDF]

Allergy Asthma Proc
Gnaensky A, Mahdavinia M, Mustafa S, Poole JA, Sher M, Tachdjian R, White A, Bernstein JS, Singh U, Bernstein JA.   +9 more
europepmc   +1 more source

Mild irritants prevent gastric necrosis through prostaglandin formation: Histological study

, 1978
A. Robert, C. Roy D. Lancaster, A.J. Hanchar, James E. Nezamis   +3 more
openalex   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source